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  1. Noninvasive diagnostic markers that are capable of distinguishing patients with colorectal cancer (CRC) from healthy individuals or patients with other cancer types are lacking. We report the discovery and val...

    Authors: Dapeng Li, Lei Zhang, Jinming Fu, Hao Huang, Yanlong Liu, Lin Zhu, Hongru Sun, Simin Sun, Ding Zhang, Tian Tian, Fan Wang, Fulan Hu, Xiaolin Peng, Gairui Li, Liyuan Zhao, Ting Zheng…
    Citation: Clinical Epigenetics 2022 14:102
  2. Vascular smooth muscle cell (VSMC) phenotype switching is critical for neointima formation, which is the major cause of restenosis after stenting or coronary artery bypass grafting. However, the epigenetic mec...

    Authors: Yi He, Xin Yi, Zihao Zhang, Hanshen Luo, Rui Li, Xin Feng, Ze-Min Fang, Xue-Hai Zhu, Wenlin Cheng, Ding-Sheng Jiang, Fang Zhao and Xiang Wei
    Citation: Clinical Epigenetics 2022 14:101
  3. CpG methylation levels can help to explain inter-individual differences in phenotypic traits. Few studies have explored whether identifying probe subsets based on their biological and statistical properties ca...

    Authors: Robert F. Hillary, Daniel L. McCartney, Allan F. McRae, Archie Campbell, Rosie M. Walker, Caroline Hayward, Steve Horvath, David J. Porteous, Kathryn L. Evans and Riccardo E. Marioni
    Citation: Clinical Epigenetics 2022 14:100
  4. Clear cell renal cell carcinoma (ccRCC) is the most common and highly heterogeneous subtype of renal cell carcinoma. Dysregulated basal cell adhesion molecule (BCAM) gene is associated with poor prognosis in vari...

    Authors: Junjie Zhao, Jiayu Liang, Yang Yang, Guangxi Sun, Xingming Zhang, Jinge Zhao, Xu Hu, Junru Chen, Sha Zhu, Yuchao Ni, Yaowen Zhang, Jindong Dai, Zhipeng Wang, Zilin Wang, Yuhao Zeng, Jin Yao…
    Citation: Clinical Epigenetics 2022 14:99
  5. Histone 3 lysine 27 (H3K27) demethylation constitutes an important epigenetic mechanism of gene activation. It is mediated by the Jumonji C domain-containing lysine demethylases KDM6A and KDM6B, both of which ...

    Authors: Jeries Abu-Hanna, Jigisha A. Patel, Evangelos Anastasakis, Richard Cohen, Lucie H. Clapp, Marilena Loizidou and Mohammad M. R. Eddama
    Citation: Clinical Epigenetics 2022 14:98
  6. Interferon gamma (IFNγ) is a pro-inflammatory cytokine that directly activates the JAK/STAT pathway. However, the temporal dynamics of chromatin remodeling and transcriptional activation initiated by IFNγ have...

    Authors: Simon J. Hogg, Olga Motorna, Conor J. Kearney, Emily B. Derrick, Imran G. House, Izabela Todorovski, Madison J. Kelly, Magnus Zethoven, Kenneth D. Bromberg, Albert Lai, Paul A. Beavis, Jake Shortt, Ricky W. Johnstone and Stephin J. Vervoort
    Citation: Clinical Epigenetics 2022 14:96
  7. Modern epigenetics emerged about 40 years ago. Since then, the field has rapidly grown. Unfortunately, this development has been accompanied by certain misconceptions and methodological shortcomings. A profoun...

    Authors: Bernhard Horsthemke
    Citation: Clinical Epigenetics 2022 14:95
  8. We recently reported the COVID-19-induced circulating leukocytes DNA methylation profile. Here, we hypothesized that some of these genes would persist differentially methylated after disease resolution. Fiftee...

    Authors: Joseph Balnis, Andy Madrid, Kirk J. Hogan, Lisa A. Drake, Anish Adhikari, Rachel Vancavage, Harold A. Singer, Reid S. Alisch and Ariel Jaitovich
    Citation: Clinical Epigenetics 2022 14:94
  9. With the rapid development of next-generation sequencing (NGS) technologies, researchers are making efforts to reveal the genomic landscape of multiple myeloma (MM). However, the clinical significance of many ...

    Authors: Lina Zhang, Run Zhang, Jing Wang, Ying Chen, Chun Qiao, Qinglin Shi, Yuanyuan Jin, Xuxing Shen, Jianyong Li and Lijuan Chen
    Citation: Clinical Epigenetics 2022 14:93
  10. SLC5A7 (solute carrier family 5 member 7), also known as choline transporter 1 (CHT1), is downregulated in colorectal cancer (CRC) and functions as a tumor suppressor. However, the mechanisms underlying the in...

    Authors: Yang Li, Baike Liu, Xiaonan Yin, Zhiyuan Jiang, Chao Fang, Na Chen, Bo Zhang, Lei Dai and Yuan Yin
    Citation: Clinical Epigenetics 2022 14:92
  11. Native Hawaiians are disproportionately affected by type 2 diabetes mellitus (DM), a chronic metabolic, non-communicable disease characterized by hyperglycemia and systemic inflammation. Unrelenting systemic i...

    Authors: Christian K. Dye, Michael J. Corley, Claire Ing, Annette Lum-Jones, Dongmei Li, Marjorie K. L. M. Mau and Alika K. Maunakea
    Citation: Clinical Epigenetics 2022 14:91
  12. Cardiovascular disease (CVD) remains the leading cause of death among postmenopausal women but standard primary prevention strategies in women are not as effective as in men. By comparison, the Early versus La...

    Authors: James R. Hilser, Jaana A. Hartiala, Intira Sriprasert, Naoko Kono, Zhiheng Cai, Roksana Karim, Joseph DeYoung, Wendy J. Mack, Howard N. Hodis and Hooman Allayee
    Citation: Clinical Epigenetics 2022 14:90
  13. Several reports have provided crucial evidence in animal models that epigenetic modifications, such as DNA methylation, may be involved in psychostimulant-induced stable changes at the cellular level in the br...

    Authors: Kaili Anier, Kelli Somelar, Külli Jaako, Margret Alttoa, Kerli Sikk, Raul Kokassaar, Kai Kisand and Anti Kalda
    Citation: Clinical Epigenetics 2022 14:89
  14. African Americans have a high risk for type 2 diabetes (T2D) and insulin resistance. Studies among other population groups have identified DNA methylation loci associated with insulin resistance, but data in A...

    Authors: Felix P. Chilunga, Karlijn A. C. Meeks, Peter Henneman, Charles Agyemang, Ayo P. Doumatey, Charles N. Rotimi and Adebowale A. Adeyemo
    Citation: Clinical Epigenetics 2022 14:88
  15. Maternal stress before, during and after pregnancy has profound effects on the development and lifelong function of the infant’s neurocognitive development. We hypothesized that the programming of the central ...

    Authors: Ritika Sharma, Martin G. Frasch, Camila Zelgert, Peter Zimmermann, Bibiana Fabre, Rory Wilson, Melanie Waldenberger, James W. MacDonald, Theo K. Bammler, Silvia M. Lobmaier and Marta C. Antonelli
    Citation: Clinical Epigenetics 2022 14:87
  16. Current noninvasive assays have limitations in the early detection of colorectal cancer. We evaluated the clinical utility of promoter methylation of the long noncoding RNA LINC00473 as a noninvasive biomarker to...

    Authors: Juan Ruiz-Bañobre, Aitor Rodriguez-Casanova, Nicolas Costa-Fraga, Aida Bao-Caamano, Ana Alvarez-Castro, Martín Carreras-Presas, Elena Brozos-Vazquez, Yolanda Vidal-Insua, Francisca Vazquez-Rivera, Sonia Candamio-Folgar, Manuel Mosquera-Presedo, Ramón M. Lago-Lestón, Laura Muinelo-Romay, José Ángel Vázquez-Bueno, Rebeca Sanz-Pamplona, Víctor Moreno…
    Citation: Clinical Epigenetics 2022 14:86
  17. DNA methylation-based GrimAge acceleration (GrimAA) is associated with a wide range of age-related health outcomes including cardiovascular disease. Since DNA methylation is modifiable by external and behavior...

    Authors: Kyeezu Kim, Yinan Zheng, Brian T. Joyce, Hongmei Jiang, Philip Greenland, David R. Jacobs Jr., Kai Zhang, Lei Liu, Norrina B. Allen, John T. Wilkins, Sarah N. Forrester, Donald M. Lloyd-Jones and Lifang Hou
    Citation: Clinical Epigenetics 2022 14:85
  18. Multiple myeloma (MM) is the second most common hematologic malignancy with almost all patients eventually having relapse or refractory MM (RRMM), thus novel drugs or combination therapies are needed for impro...

    Authors: Liqin Cao, Qingxiao Chen, Huiyao Gu, Yi Li, Wen Cao, Yang Liu, Jianwei Qu, Yifan Hou, Jing Chen, Enfan Zhang, Jingsong He and Zhen Cai
    Citation: Clinical Epigenetics 2022 14:84
  19. Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have bee...

    Authors: Sara Sammallahti, M. Elisabeth Koopman-Verhoeff, Anne-Claire Binter, Rosa H. Mulder, Alba Cabré-Riera, Tuomas Kvist, Anni L. K. Malmberg, Giancarlo Pesce, Sabine Plancoulaine, Jonathan A. Heiss, Sheryl L. Rifas-Shiman, Stefan W. Röder, Anne P. Starling, Rory Wilson, Kathrin Guerlich, Kristine L. Haftorn…
    Citation: Clinical Epigenetics 2022 14:83
  20. Given the global increase in air pollution and its crucial role in human health, as well as the steep rise in prevalence of metabolic syndrome (MetS), a better understanding of the underlying mechanisms by whi...

    Authors: Parinaz Poursafa, Zoha Kamali, Eliza Fraszczyk, H. Marike Boezen, Ahmad Vaez and Harold Snieder
    Citation: Clinical Epigenetics 2022 14:82
  21. Epigenetic abnormalities in DNA hydroxymethylation (5hmC) have been detected in patients with myeloid neoplasms, suggesting that 5hmC might act as a valuable epigenetic mark to reflect the disease status of my...

    Authors: Jia Li, Tingting Hong, Yue Wei, Lei Guo, Minjung Lee, Hui Yang, Caleb Class, Yaling Yang, Xiaoqiong Wang, Hua He, Stefan Siwko, M. James You, Yubin Zhou, Guillermo Garcia-Manero and Yun Huang
    Citation: Clinical Epigenetics 2022 14:81
  22. There is an increasing interest in the role of epigenetics in epidemiology, but the emerging research field faces several critical biological and technical challenges. In particular, recent studies have shown ...

    Authors: Emilie Willoch Olstad, Hedvig Marie Egeland Nordeng, Geir Kjetil Sandve, Robert Lyle and Kristina Gervin
    Citation: Clinical Epigenetics 2022 14:80
  23. Despite the brain’s high demand for energy, research on its epigenetics focuses on nuclear methylation, and much of the mitochondrial DNA methylation remains seldom investigated. With a focus on the nucleus ac...

    Authors: Chia-Hung Huang, Man-Chen Chang, Yung-Chun Lai, Chun-Yen Lin, Cho-Hsien Hsu, Bo-Yuan Tseng, Chuhsing Kate Hsiao, Tzu-Pin Lu, Sung-Liang Yu, Sung-Tsang Hsieh and Wei J. Chen
    Citation: Clinical Epigenetics 2022 14:79
  24. Adverse birth outcomes, such as early gestational age and low birth weight, can have lasting effects on morbidity and mortality, with impacts that persist into adulthood. Identifying the maternal factors that ...

    Authors: Calen P. Ryan, Raviraj J. Rege, Nanette R. Lee, Delia B. Carba, Michael S. Kobor, Julie L. MacIsaac, David S. Lin, Parmida Atashzay and Christopher W. Kuzawa
    Citation: Clinical Epigenetics 2022 14:78
  25. Despite the efforts to describe the molecular landscape of esophageal adenocarcinoma (EAC) and its precursor lesion Barrett’s esophagus (BE), discrepant findings are reported. Here, we investigated the prevale...

    Authors: Rita Pinto, Tobias Hauge, Marine Jeanmougin, Heidi D. Pharo, Stine H. Kresse, Hilde Honne, Sara B. Winge, May-Britt Five, Theresa Kumar, Tom Mala, Truls Hauge, Egil Johnson and Guro E. Lind
    Citation: Clinical Epigenetics 2022 14:77
  26. Considerable effort has been spent on lowering and maintaining the epigenetic age. However, the extent to which epigenetic age fluctuates under normal conditions is poorly understood. Therefore, we analyzed me...

    Authors: Shohei Komaki, Hideki Ohmomo, Tsuyoshi Hachiya, Yoichi Sutoh, Kanako Ono, Ryohei Furukawa, So Umekage, Yayoi Otsuka-Yamasaki, Shiori Minabe, Akira Takashima, Kozo Tanno, Makoto Sasaki and Atsushi Shimizu
    Citation: Clinical Epigenetics 2022 14:76
  27. Epigenetic modifications, including DNA methylation (DNAm), are often related to environmental exposures, and are increasingly recognized as key processes in the pathogenesis of chronic lung disease. American ...

    Authors: Arce Domingo-Relloso, Angela L. Riffo-Campos, Martha Powers, Maria Tellez-Plaza, Karin Haack, Robert H. Brown, Jason G. Umans, M. Daniele Fallin, Shelley A. Cole, Ana Navas-Acien and Tiffany R. Sanchez
    Citation: Clinical Epigenetics 2022 14:75
  28. Ovarian cancer (OC) is a highly lethal gynecologic cancer, and it is hard to diagnose at an early stage. Clinically, there are no ovarian cancer-specific markers for early detection. Here, we demonstrate the u...

    Authors: Huaiwu Lu, Yunyun Liu, Jingyu Wang, Shaliu Fu, Lingping Wang, Chunxian Huang, Jing Li, Lingling Xie, Dongyan Wang, Dan Li, Hui Zhou and Qunxian Rao
    Citation: Clinical Epigenetics 2022 14:74
  29. Cardiovascular health (CVH) was defined by the American Heart Association as an integrative idealness of seven clinical or lifestyle factors. Based on populations of European ancestry, recent studies have show...

    Authors: Yun-Hsiang Lo and Wan-Yu Lin
    Citation: Clinical Epigenetics 2022 14:73
  30. Cigarette smoke is a major public health concern. Epigenetic aging may be an important pathway by which exposure to cigarette smoke affects health. However, little is known about how exposure to smoke at diffe...

    Authors: Eric T. Klopack, Judith E. Carroll, Steve W. Cole, Teresa E. Seeman and Eileen M. Crimmins
    Citation: Clinical Epigenetics 2022 14:72
  31. Beckwith–Wiedemann syndrome (BWS) and Pseudohypoparathyroidism type 1B (PHP1B) are imprinting disorders (ID) caused by deregulation of the imprinted gene clusters located at 11p15.5 and 20q13.32, respectively....

    Authors: Laura Pignata, Francesco Cecere, Ankit Verma, Bruno Hay Mele, Maria Monticelli, Basilia Acurzio, Carlo Giaccari, Angela Sparago, Jose Ramon Hernandez Mora, Ana Monteagudo-Sánchez, Manel Esteller, Arrate Pereda, Jair Tenorio-Castano, Orazio Palumbo, Massimo Carella, Paolo Prontera…
    Citation: Clinical Epigenetics 2022 14:71
  32. Alterations in histone modifications have been reported to be related to tumorigenicity and tumor progression. However, whether histone modification can aid the classification of patients or influence clinical...

    Authors: Rui Zhou, Fuli Xie, Kuncai Liu, Xuee Zhou, Xuemei Chen, Jinzhang Chen, Shaoyan Xi, Zhenhua Huang and Xiaoxiang Rong
    Citation: Clinical Epigenetics 2022 14:70
  33. Gestational diabetes mellitus (GDM) is a common pregnancy-specific disease and is growing at an alarming rate worldwide, which can negatively affect the health of pregnant women and fetuses. However, most stud...

    Authors: Sha Lu, Jiahao Wang, Nisile Kakongoma, Wen Hua, Jiahui Xu, Yunfei Wang, Shutao He, Hongcang Gu, Jiantao Shi and Wensheng Hu
    Citation: Clinical Epigenetics 2022 14:69
  34. The epigenetic changes associated with melanoma progression to advanced and metastatic stages are still poorly understood. To shed light on the CpG methylation dynamics during melanoma development, we analyzed...

    Authors: Flávia E. Rius, Debora D. Papaiz, Hatylas F. Z. Azevedo, Ana Luísa P. Ayub, Diogo O. Pessoa, Tiago F. Oliveira, Ana Paula M. Loureiro, Fernando Andrade, André Fujita, Eduardo M. Reis, Christopher E. Mason and Miriam G. Jasiulionis
    Citation: Clinical Epigenetics 2022 14:68
  35. Childhood overweight/obesity is a global public health concern. It is important to identify its early-life risk factors. Maternal poor sleep is common in late pregnancy, and previous studies indicated that poo...

    Authors: Min Meng, Yanrui Jiang, Jianfei Lin, Jun Zhang, Guanghai Wang, Qi Zhu, Qingmin Lin and Fan Jiang
    Citation: Clinical Epigenetics 2022 14:66
  36. Recombinant human growth hormone (rhGH) has shown a great growth-promoting potential in children with idiopathic short stature (ISS). However, the response to rhGH differs across individuals, largely due to ge...

    Authors: Xiaojian Shao, Catherine Le Stunff, Warren Cheung, Tony Kwan, Mark Lathrop, Tomi Pastinen and Pierre Bougnères
    Citation: Clinical Epigenetics 2022 14:65
  37. Placental mesenchymal dysplasia (PMD) is a morphological abnormality resembling partial hydatidiform moles. It is often associated with androgenetic/biparental mosaicism (ABM) and complicated by Beckwith–Wiede...

    Authors: Saori Aoki, Ken Higashimoto, Hidenori Hidaka, Yasufumi Ohtsuka, Shigehisa Aoki, Hiroyuki Mishima, Koh-ichiro Yoshiura, Kazuhiko Nakabayashi, Kenichiro Hata, Hitomi Yatsuki, Satoshi Hara, Takashi Ohba, Hidetaka Katabuchi and Hidenobu Soejima
    Citation: Clinical Epigenetics 2022 14:64
  38. We previously showed that continued folic acid (FA) supplementation beyond the first trimester of pregnancy appears to have beneficial effects on neurocognitive performance in children followed for up to 11 ye...

    Authors: Miroslava Ondičová, Rachelle E. Irwin, Sara-Jayne Thursby, Luke Hilman, Aoife Caffrey, Tony Cassidy, Marian McLaughlin, Diane J. Lees-Murdock, Mary Ward, Michelle Murphy, Yvonne Lamers, Kristina Pentieva, Helene McNulty and Colum P. Walsh
    Citation: Clinical Epigenetics 2022 14:63
  39. Sex differences are known to play a role in disease aetiology, progression and outcome. Previous studies have revealed autosomal epigenetic differences between males and females in some tissues, including diff...

    Authors: Olivia A. Grant, Yucheng Wang, Meena Kumari, Nicolae Radu Zabet and Leonard Schalkwyk
    Citation: Clinical Epigenetics 2022 14:62
  40. Circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) analysis represents a liquid biopsy approach for real-time monitoring of tumor evolution. DNA methylation is considered to be an early event in ...

    Authors: Α. Markou, D. Londra, V. Tserpeli, Ι. Kollias, E. Tsaroucha, I. Vamvakaris, K. Potaris, I. Pateras, Α. Kotsakis, V. Georgoulias and Ε. Lianidou
    Citation: Clinical Epigenetics 2022 14:61
  41. The androgen receptor (AR) is a prostate master transcription factor. It binds to genetic enhancers, where it regulates gene activity and plays a fundamental role in prostate pathophysiology. Previous work has...

    Authors: Tesa Severson, Xintao Qiu, Mohammed Alshalalfa, Martin Sjöström, David Quigley, Andries Bergman, Henry Long, Felix Feng, Matthew L. Freedman, Wilbert Zwart and Mark M. Pomerantz
    Citation: Clinical Epigenetics 2022 14:60
  42. Unbalanced iron homeostasis in pregnancy is associated with an increased risk of adverse birth and childhood health outcomes. DNA methylation has been suggested as a potential underlying mechanism linking envi...

    Authors: M. J. Taeubert, P. de Prado-Bert, M. L. Geurtsen, G. Mancano, M. J. Vermeulen, I. K. M. Reiss, D. Caramaschi, J. Sunyer, G. C. Sharp, J. Julvez, M. U. Muckenthaler and J. F. Felix
    Citation: Clinical Epigenetics 2022 14:59
  43. Genomic technologies can be subject to significant batch-effects which are known to reduce experimental power and to potentially create false positive results. The Illumina Infinium Methylation BeadChip is a p...

    Authors: Jason P. Ross, Susan van Dijk, Melinda Phang, Michael R. Skilton, Peter L. Molloy and Yalchin Oytam
    Citation: Clinical Epigenetics 2022 14:58
  44. Bronchopulmonary dysplasia (BPD) is a lung disease in premature infants caused by therapeutic oxygen supplemental and characterized by impaired pulmonary development which persists into later life. While advan...

    Authors: Xuting Wang, Hye-Youn Cho, Michelle R. Campbell, Vijayalakshmi Panduri, Silvina Coviello, Mauricio T. Caballero, Deepa Sambandan, Steven R. Kleeberger, Fernando P. Polack, Gaston Ofman and Douglas A. Bell
    Citation: Clinical Epigenetics 2022 14:57
  45. DNA methylation biomarkers for early detection, risk stratification and treatment response in cancer have been of great interest over the past decades. Nevertheless, clinical implementation of these biomarkers...

    Authors: Maartje Massen, Kim Lommen, Kim A. D. Wouters, Johan Vandersmissen, Wim van Criekinge, James G. Herman, Veerle Melotte, Leo J. Schouten, Manon van Engeland and Kim M. Smits
    Citation: Clinical Epigenetics 2022 14:56
  46. Panic disorder (PD) is characterized by recurrent panic attacks and higher affection of women as compared to men. The lifetime prevalence of PD is about 2–3% in the general population leading to tremendous dis...

    Authors: Darina Czamara, Alexa Neufang, Roman Dieterle, Stella Iurato, Janine Arloth, Jade Martins, Marcus Ising, Elisabeth E. Binder and Angelika Erhardt
    Citation: Clinical Epigenetics 2022 14:55
  47. Conflicting results regarding alterations to sperm DNA methylation in cases of spermatogenesis defects, male infertility and poor developmental outcomes have been reported in humans. Bulls used for artificial ...

    Authors: Valentin Costes, Aurélie Chaulot-Talmon, Eli Sellem, Jean-Philippe Perrier, Anne Aubert-Frambourg, Luc Jouneau, Charline Pontlevoy, Chris Hozé, Sébastien Fritz, Mekki Boussaha, Chrystelle Le Danvic, Marie-Pierre Sanchez, Didier Boichard, Laurent Schibler, Hélène Jammes, Florence Jaffrézic…
    Citation: Clinical Epigenetics 2022 14:54
  48. epi-cblC is a recently discovered inherited disorder of intracellular vitamin B12 metabolism associating hematological, neurological, and cardiometabolic outcomes. It is produced by an epimutation at the promoter...

    Authors: Abderrahim Oussalah, Youssef Siblini, Sébastien Hergalant, Céline Chéry, Pierre Rouyer, Catia Cavicchi, Renzo Guerrini, Pierre-Emmanuel Morange, David Trégouët, Mihaela Pupavac, David Watkins, Tomi Pastinen, Wendy K. Chung, Can Ficicioglu, François Feillet, D. Sean Froese…
    Citation: Clinical Epigenetics 2022 14:52