Skip to main content

Articles

Page 1 of 35

  1. Gestational exposure to ambient air pollution has been associated with adverse health outcomes for mothers and newborns. The placenta is a central regulator of the in utero environment that orchestrates develo...

    Authors: Hachem Saddiki, Xueying Zhang, Elena Colicino, Ander Wilson, Itai Kloog, Robert O. Wright, Rosalind J. Wright and Corina Lesseur
    Citation: Clinical Epigenetics 2023 15:188
    Content type: Research Published on:

  2. Overexpressed EZH2 is oncogenically involved in the pathogenesis of different cancerous contexts including extranodal natural killer/T cell lymphoma (ENKTL). However, the underlying mechanisms of EZH2 upregula...

    Authors: Boheng Li, Qidi Zhou, Qin Wan, Xuan Qiao, Shangying Chen, Jianbiao Zhou, Zhijun Wuxiao, Lei Luo, Siok-Bian Ng, Jieping Li and Wee-Joo Chng
    Citation: Clinical Epigenetics 2023 15:187
    Content type: Research Published on:

  3. Aging has been reported as a major risk factor for severe symptoms and higher mortality rates in COVID-19 patients. Molecular hallmarks such as epigenetic alterations and telomere attenuation reflect the biolo...

    Authors: Yosra Bejaoui, Fathima Humaira Amanullah, Mohamad Saad, Sara Taleb, Martina Bradic, Andre Megarbane, Ali Ait Hssain, Charbel Abi Khalil and Nady El Hajj
    Citation: Clinical Epigenetics 2023 15:186
    Content type: Research Published on:

  4. Elderly patients with AML ineligible for induction have a dismal prognosis; hence disease stabilization is a primary treatment goal. This case of a 75-year-old patient with secondary AML receiving the combinat...

    Authors: Nora Rebeka Javorniczky, Olga Grishina, Inga Hund, Milena Pantic, Dietmar Pfeifer, Claudia Schmoor, Johanna Thomas, Justus Duyster, Heiko Becker and Michael Lübbert
    Citation: Clinical Epigenetics 2023 15:185
    Content type: Brief Report Published on:

  5. Cardiovascular disease (CVD) remains a major health killer worldwide, and the role of epigenetic regulation in CVD has been widely studied in recent decades. Herein, we perform a bibliometric study to decipher...

    Authors: Yukang Mao, Kun Zhao, Nannan Chen, Qiangqiang Fu, Yimeng Zhou, Chuiyu Kong, Peng Li and Chuanxi Yang
    Citation: Clinical Epigenetics 2023 15:184
    Content type: Review Published on:

  6. Activation of dominant oncogenes by small or structural genomic alterations is a common driver mechanism in many cancers. Silencing of such dominantly activated oncogenic alleles, thus, is a promising strategy...

    Authors: Alexandra G. Kouroukli, Nivethika Rajaram, Pavel Bashtrykov, Helene Kretzmer, Reiner Siebert, Albert Jeltsch and Susanne Bens
    Citation: Clinical Epigenetics 2023 15:183
    Content type: Research Published on:

  7. Epithelial mesenchymal transformation (EMT) in alveolar type 2 epithelial cells (AT2) is closely associated with pulmonary fibrosis (PF). Histone deacetylase 3 (HDAC3) is an important enzyme that regulates pro...

    Authors: Rui Xiong, Boxin Geng, Wenyang Jiang, Yong Hu, Zhaoyu Hu, Bo Hao, Ning Li and Qing Geng
    Citation: Clinical Epigenetics 2023 15:182
    Content type: Research Published on:

  8. Puberty is a highly heritable and variable trait, with environmental factors having a role in its eventual timing and development. Early and late pubertal onset are both associated with various diseases develo...

    Authors: Emir Sehovic, Stephanie M. Zellers, Markus K. Youssef, Aino Heikkinen, Jaakko Kaprio and Miina Ollikainen
    Citation: Clinical Epigenetics 2023 15:181
    Content type: Research Published on:

  9. Hepatocellular carcinoma (HCC) is one of the global health concerns. Hepatitis B virus (HBV) is one of the major causes of HCC. Poor clinical outcome of HCC patients is attributed to a small population of canc...

    Authors: Mohamed N. Amin, Yousra M. El-Far, Mohammed El-Mowafy and Abdelaziz Elgaml
    Citation: Clinical Epigenetics 2023 15:180
    Content type: Research Published on:

  10. Authors: Giulia Stazi, Ludovica Taglieri, Alice Nicolai, Annalisa Romanelli, Rossella Fioravanti, Stefania Morrone, Manuela Sabatino, Rino Ragno, Samanta Taurone, Marcella Nebbioso, Raffaella Carletti, Marco Artico, Sergio Valente, Susanna Scarpa and Antonello Mai
    Citation: Clinical Epigenetics 2023 15:179
    Content type: Retraction Note Published on:

  11. The role of PRKAG2 in the maintenance of heart function is well established, but little is known about how PRKAG2 is regulated in cardiomyocytes. In this study, we investigated the role of the lncRNA PRKAG2-AS, w...

    Authors: Xiao-Wei Song, Ting Su, Bo Li, Yun-Jie Huang, Wen-Xia He, Li-Li Jiang, Chang-Jin Li, Song-Qun Huang, Song-Hua Li, Zhi-Fu Guo, Hong Wu and Bi-Li Zhang
    Citation: Clinical Epigenetics 2023 15:178
    Content type: Research Published on:

  12. Cholangiocarcinoma (CCA) refers to a collection of malignant tumors that develop from the biliary epithelium. Extensive clinical evidence and epidemiological observations indicate a concerning increase in both...

    Authors: Guanhua Wu, Da Wang, Fei Xiong, Wenzheng Liu, Qi Wang, Junsheng Chen, Bing Wang and Yongjun Chen
    Citation: Clinical Epigenetics 2023 15:177
    Content type: Research Published on:

  13. Facial aging is the most visible manifestation of aging. People desire to look younger than others of the same chronological age. Hence, perceived age is often used as a visible marker of aging, while biologic...

    Authors: Klemo Vladimir, Marija Majda Perišić, Mario Štorga, Ali Mostashari and Raya Khanin
    Citation: Clinical Epigenetics 2023 15:176
    Content type: Research Published on:

  14. Huazhuo Tiaozhi granule (HTG) is a herbal medicine formula widely used in clinical practice for hypolipidaemic effects. However, the molecular mechanisms underlying dyslipidaemia treatment have not been well e...

    Authors: Xiangjun Yin, Min Li, Yongzhi Wang, Guifang Zhao, Tao Yang, Yuqing Zhang, Jianbo Guo, Tiantian Meng, Ruolin Du, Honglin Li, Zhe Wang, Jian Zhang and Qingyong He
    Citation: Clinical Epigenetics 2023 15:175
    Content type: Research Published on:

  15. Alpha (α)-radiation is a ubiquitous environmental agent with epigenotoxic effects. Human exposure to α-radiation at potentially harmful levels can occur repetitively over the long term via inhalation of natura...

    Authors: Marilyn N. Vera-Chang, John M. Danforth, Marilyne Stuart, Aaron A. Goodarzi, Marjorie Brand and Richard B. Richardson
    Citation: Clinical Epigenetics 2023 15:174
    Content type: Research Published on:

  16. Insulin resistance (IR) is a major risk factor for Alzheimer’s disease (AD) dementia. The mechanisms by which IR predisposes to AD are not well-understood. Epigenetic studies may help identify molecular signat...

    Authors: Chloé Sarnowski, Tianxiao Huan, Yiyi Ma, Roby Joehanes, Alexa Beiser, Charles S. DeCarli, Nancy L. Heard-Costa, Daniel Levy, Honghuang Lin, Ching-Ti Liu, Chunyu Liu, James B. Meigs, Claudia L. Satizabal, Jose C. Florez, Marie-France Hivert, Josée Dupuis…
    Citation: Clinical Epigenetics 2023 15:173
    Content type: Research Published on:

  17. Recent findings from studies of mouse models of Mendelian disorders of epigenetic machinery strongly support the potential for postnatal therapies to improve neurobehavioral and cognitive deficits. As several ...

    Authors: Sarah Jessica Goodman, Teresa Romeo Luperchio, Jacob Ellegood, Eric Chater-Diehl, Jason P. Lerch, Hans Tomas Bjornsson and Rosanna Weksberg
    Citation: Clinical Epigenetics 2023 15:172
    Content type: Research Published on:

  18. Acute myeloid leukemia (AML) is a heterogeneous disease with a poor prognosis. Dysregulation of the epigenetic machinery is a significant contributor to disease development. Some AML patients benefit from trea...

    Authors: Maximilian Schmutz, Manuela Zucknick, Richard F. Schlenk, Daniel Mertens, Axel Benner, Dieter Weichenhan, Oliver Mücke, Konstanze Döhner, Christoph Plass, Lars Bullinger and Rainer Claus
    Citation: Clinical Epigenetics 2023 15:171
    Content type: Research Published on:

  19. Multiple mechanisms are involved in kidney damage, among which the role of epigenetic modifications in the occurrence and development of kidney diseases is constantly being revealed. However, N6-methyladenosin...

    Authors: Qimeng Wang, Xiaoting Fan, Qinghao Sheng, Meilin Yang, Ping Zhou, Shangwei Lu, Ying Gao, Zhijuan Kong, Ning Shen, Zhimei Lv and Rong Wang
    Citation: Clinical Epigenetics 2023 15:170
    Content type: Review Published on:

  20. Heterozygous SNVs or CNV deletions involving the FOXF1 gene, or its distant enhancer, are causative for 80–90% of cases of alveolar capillary dysplasia with misalignment of pulmonary veins. Recently, we proposed ...

    Authors: Przemyslaw Szafranski, Rijutha P. Garimella, Haresh Mani, Ryan Hartman, Gail Deutsch, Alan Silk, Alan Benheim and Paweł Stankiewicz
    Citation: Clinical Epigenetics 2023 15:169
    Content type: Research Published on:

  22. Rhabdomyosarcomas (RMS) are predominantly paediatric sarcomas thought to originate from muscle precursor cells due to impaired myogenic differentiation. Despite intensive treatment, 5-year survival for patient...

    Authors: Eleanor O’Brien, Carmen Tse, Ian Tracy, Ian Reddin, Joanna Selfe, Jane Gibson, William Tapper, Reuben J. Pengelly, Jinhui Gao, Ewa Aladowicz, Gemma Petts, Khin Thway, Sergey Popov, Anna Kelsey, Timothy J. Underwood, Janet Shipley…
    Citation: Clinical Epigenetics 2023 15:167
    Content type: Research Published on:

  23. B vitamins such as folate (B9), B6, and B12 are key in one carbon metabolism, which generates methyl donors for DNA methylation. Several studies have linked differential methylation to self-reported intakes of...

    Authors: Ricardo Costeira, Laila Evangelista, Rory Wilson, Xinyu Yan, Fabian Hellbach, Lucy Sinke, Colette Christiansen, Sergio Villicaña, Olatz M. Masachs, Pei-Chien Tsai, Massimo Mangino, Cristina Menni, Sarah E. Berry, Marian Beekman, Diana van Heemst, P. Eline Slagboom…
    Citation: Clinical Epigenetics 2023 15:166
    Content type: Research Published on:

  25. DNA methylation (DNAm) age acceleration (AgeAccel) and cardiac age by 12-lead advanced electrocardiography (A-ECG) are promising biomarkers of biological and cardiac aging, respectively. We aimed to explore th...

    Authors: Constantin-Cristian Topriceanu, Eesha Dev, Mahmood Ahmad, Rebecca Hughes, Hunain Shiwani, Matthew Webber, Kenan Direk, Andrew Wong, Martin Ugander, James C. Moon, Alun D. Hughes, Jane Maddock, Todd T. Schlegel and Gabriella Captur
    Citation: Clinical Epigenetics 2023 15:164
    Content type: Research Published on:

  26. Gastric cancer patients harboring a TP53 mutation exhibit a more aggressive and chemoresistant phenotype. Unfortunately, efforts to identify the vulnerabilities to overcome these aggressive malignancies have made...

    Authors: Kaiqing Wang, Zhicheng Gong, Yanyan Chen, Meimei Zhang, Suzeng Wang, Surui Yao, Zhihui Liu, Zhaohui Huang and Bojian Fei
    Citation: Clinical Epigenetics 2023 15:163
    Content type: Research Published on:

  27. Adverse childhood experiences (ACEs) increase the risk of poor health outcomes later in life. Psychosocial stressors may also have intergenerational health effects by which parental ACEs are associated with me...

    Authors: Phillip Collender, Anne K. Bozack, Stephanie Veazie, Jamaji C. Nwanaji-Enwerem, Lars Van Der Laan, Katherine Kogut, Corinne Riddell, Brenda Eskenazi, Nina Holland, Julianna Deardorff and Andres Cardenas
    Citation: Clinical Epigenetics 2023 15:162
    Content type: Research Published on:

  28. Previous studies have traditionally attributed the initiation of cancer cells to genetic mutations, considering them as the fundamental drivers of carcinogenesis. However, recent research has shed light on the...

    Authors: Yuhua Hu, Feng Shen, Xi Yang, Tingting Han, Zhuowen Long, Jiale Wen, Junxing Huang, Jiangfeng Shen and Qing Guo
    Citation: Clinical Epigenetics 2023 15:161
    Content type: Review Published on:

  29. Cigarette smoking and aging are the main risk factors for pulmonary diseases, including cancer. Epigenetic aging may explain the relationship between smoking, electronic cigarette vaping, and pulmonary health....

    Authors: Min-Ae Song, Kellie M. Mori, Joseph P. McElroy, Jo L. Freudenheim, Daniel Y. Weng, Sarah A. Reisinger, Theodore M. Brasky, Mark D. Wewers and Peter G. Shields
    Citation: Clinical Epigenetics 2023 15:160
    Content type: Research Published on:

  30. Epigenetic clocks constructed from DNA methylation patterns have emerged as excellent predictors of aging and aging-related health outcomes. Iron, a crucial element, is meticulously regulated within organisms,...

    Authors: Zhihao Wang, Yi Liu, Shuxin Zhang, Yunbo Yuan, Siliang Chen, Wenhao Li, Mingrong Zuo, Yufan Xiang, Tengfei Li, Wanchun Yang, Yuan Yang and Yanhui Liu
    Citation: Clinical Epigenetics 2023 15:159
    Content type: Research Published on:

  31. MTR gene encodes the cytoplasmic enzyme methionine synthase, which plays a pivotal role in the methionine cycle of one-carbon metabolism. This cycle holds a significant importance in generating S-adenosylmethioni...

    Authors: Karim Matmat, Jean-Baptiste Conart, Paul-Henri Graindorge, Sandra El Kouche, Ziad Hassan, Youssef Siblini, Rémy Umoret, Ramia Safar, Okan Baspinar, Aurélie Robert, Jean-Marc Alberto, Abderrahim Oussalah, David Coelho, Jean-Louis Guéant and Rosa-Maria Guéant-Rodriguez
    Citation: Clinical Epigenetics 2023 15:158
    Content type: Research Published on:

  32. Early detection has proven to be the most effective strategy to reduce the incidence and mortality of colorectal cancer (CRC). Nevertheless, most current screening programs suffer from low participation rates....

    Authors: María Gallardo-Gómez, Mar Rodríguez-Girondo, Núria Planell, Sebastian Moran, Luis Bujanda, Ane Etxart, Antoni Castells, Francesc Balaguer, Rodrigo Jover, Manel Esteller, Joaquín Cubiella, David Gómez-Cabrero and Loretta De Chiara
    Citation: Clinical Epigenetics 2023 15:157
    Content type: Research Published on:

  33. Albuterol is the first-line asthma medication used in diverse populations. Although DNA methylation (DNAm) is an epigenetic mechanism involved in asthma and bronchodilator drug response (BDR), no study has ass...

    Authors: Javier Perez-Garcia, Maria Pino-Yanes, Elizabeth G. Plender, Jamie L. Everman, Celeste Eng, Nathan D. Jackson, Camille M. Moore, Kenneth B. Beckman, Vivian Medina, Sunita Sharma, Daniel Efrain Winnica, Fernando Holguin, José Rodríguez-Santana, Jesús Villar, Elad Ziv, Max A. Seibold…
    Citation: Clinical Epigenetics 2023 15:156
    Content type: Research Published on:

  34. Epigenetic changes can bring insight into gene regulatory mechanisms associated with disease pathogenicity, including chronicity and increased vulnerability. To date, we are yet to identify genes sensitive to ...

    Authors: Maria Maiarù, Richard J. Acton, Eva L. Woźniak, Charles A. Mein, Christopher G. Bell and Sandrine M. Géranton
    Citation: Clinical Epigenetics 2023 15:155
    Content type: Research Published on:

  35. In observational studies, women’s fertility and sexual development traits may have implications for DNA methylation patterns, and pregnancy-related risk factors can also affect maternal DNA methylation pattern...

    Authors: Boxin Zhang, Qizhi Yuan, Yining Luan and Jian Xia
    Citation: Clinical Epigenetics 2023 15:154
    Content type: Research Published on:

  36. Multiple genetic and epigenetic regulatory mechanisms play a vital role in tumorigenesis and development. Understanding the interplay between different epigenetic modifications and its contribution to transcri...

    Authors: Kesong Shi, Rula Sa, Le Dou, Yuan Wu, Zhiqiang Dong, Xinyao Fu and Haiquan Yu
    Citation: Clinical Epigenetics 2023 15:153
    Content type: Research Published on:

  38. DNA methylation biomarkers in circulating cell-free DNA (cfDNA) have great clinical potential for cancer management. Most methods for DNA methylation analysis require bisulfite conversion, causing DNA degradat...

    Authors: Stine H. Kresse, Sara Brandt-Winge, Heidi Pharo, Bjørnar T. B. Flatin, Marine Jeanmougin, Hege Marie Vedeld and Guro E. Lind
    Citation: Clinical Epigenetics 2023 15:151
    Content type: Research Published on:

  39. Acute myeloid leukaemia (AML) is a deadly disease characterised by the uncontrolled proliferation of immature myeloid cells within the bone marrow. Altered regulation of DNA methylation is an important epigene...

    Authors: Sam Humphries, Danielle R. Bond, Zacary P. Germon, Simon Keely, Anoop K. Enjeti, Matthew D. Dun and Heather J. Lee
    Citation: Clinical Epigenetics 2023 15:150
    Content type: Review Published on:

  40. Aortic stenosis (AS) is one of the most common cardiac diseases and major cause of morbidity and mortality in the elderly. Transcatheter aortic valve implantation (TAVI) is performed in such patients with symp...

    Authors: Leon Kanwischer, Xingbo Xu, Afifa Binta Saifuddin, Sabine Maamari, Xiaoying Tan, Fouzi Alnour, Björn Tampe, Thomas Meyer, Michael Zeisberg, Gerd Hasenfuss, Miriam Puls and Elisabeth M. Zeisberg
    Citation: Clinical Epigenetics 2023 15:149
    Content type: Research Published on:

  41. Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molec...

    Authors: Latha Kadalayil, Md. Zahangir Alam, Cory Haley White, Akram Ghantous, Esther Walton, Olena Gruzieva, Simon Kebede Merid, Ashish Kumar, Ritu P. Roy, Olivia Solomon, Karen Huen, Brenda Eskenazi, Peter Rzehak, Veit Grote, Jean-Paul Langhendries, Elvira Verduci…
    Citation: Clinical Epigenetics 2023 15:148
    Content type: Research Published on:

  42. Blood-based DNA methylation has shown great promise as a biomarker in a wide variety of diseases. Studies of DNA methylation in blood often utilize samples which have been cryopreserved for years or even decad...

    Authors: Ning Yuan Lee, Melissa Hum, Guek Peng Tan, Ai Choo Seah, Patricia T. Kin, Ngiap Chuan Tan, Hai-Yang Law and Ann S. G. Lee
    Citation: Clinical Epigenetics 2023 15:147
    Content type: Research Published on:

  43. Dysregulation of histone modifications has been implicated in the pathogenesis of both inflammatory bowel disease (IBD) and colorectal cancer (CRC). These diseases are characterized by chronic inflammation, an...

    Authors: Bing Liang, Yanhong Wang, Jiazhen Xu, Yingchun Shao and Dongming Xing
    Citation: Clinical Epigenetics 2023 15:146
    Content type: Review Published on:

  44. Epigenetic mechanisms are informational cellular processes instructing normal and diseased phenotypes. They are associated with DNA but without altering the DNA sequence. Whereas chemical processes like DNA me...

    Authors: Reiner Siebert, Ole Ammerpohl, Mirko Rossini, Dennis Herb, Sven Rau, Martin B. Plenio, Fedor Jelezko and Joachim Ankerhold
    Citation: Clinical Epigenetics 2023 15:145
    Content type: Hypothesis Published on:

  45. First-degree relatives of type 2 diabetics (FDR) exhibit a high risk of developing type 2 diabetes (T2D) and feature subcutaneous adipocyte hypertrophy, independent of obesity. In FDR, adipose cell abnormaliti...

    Authors: Michele Longo, Federica Zatterale, Rosa Spinelli, Jamal Naderi, Luca Parrillo, Pasqualina Florese, Cecilia Nigro, Alessia Leone, Augusta Moccia, Antonella Desiderio, Gregory A. Raciti, Claudia Miele, Ulf Smith and Francesco Beguinot
    Citation: Clinical Epigenetics 2023 15:144
    Content type: Research Published on:

  47. Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination.

    Authors: Fang Fang, Linran Zhou, Wei Perng, Carmen J. Marsit, Anna K. Knight, Andres Cardenas, Max T. Aung, Marie-France Hivert, Izzuddin M. Aris, Jaclyn M. Goodrich, Alicia K. Smith, Abigail Gaylord, Rebecca C. Fry, Emily Oken, George O’Connor, Douglas M. Ruden…
    Citation: Clinical Epigenetics 2023 15:142
    Content type: Research Published on:

  48. Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted specifically through male germ cells. Studies in humans are, however, limited. We...

    Authors: Negusse Tadesse Kitaba, Gerd Toril Mørkve Knudsen, Ane Johannessen, Faisal I. Rezwan, Andrei Malinovschi, Anna Oudin, Bryndis Benediktsdottir, David Martino, Francisco Javier Callejas González, Leopoldo Palacios Gómez, Mathias Holm, Nils Oskar Jõgi, Shyamali C. Dharmage, Svein Magne Skulstad, Sarah H. Watkins, Matthew Suderman…
    Citation: Clinical Epigenetics 2023 15:131
    Content type: Research Published on:

  50. Vitamin D might have anti-tumor effect, which is affected by the genes related to vitamin D metabolic pathway. Epigenetic mechanism may affect the expression level of vitamin D metabolic pathway related genes,...

    Authors: Yi-Fan Wang, Lei Li, Xue-Qing Deng, Yu-Jing Fang and Cai-Xia Zhang
    Citation: Clinical Epigenetics 2023 15:140
    Content type: Research Published on:
Submit manuscript

Follow

  • ISSN: 1868-7083 (electronic)

Clinical Epigenetics

ISSN: 1868-7083

Contact us