Skip to main content

Advertisement

Articles

Page 1 of 18

  1. Identifying subjects with a high risk of ischemic stroke is fundamental for prevention of the disease. Both genetic and environmental risk factors contribute to ischemic stroke, but the underlying epigenetic m...

    Authors: Xueying Qin, Jin Li, Tao Wu, Yiqun Wu, Xun Tang, Pei Gao, Lin Li, Mengying Wang, Yao Wu, Xiaowen Wang, Dafang Chen and Yonghua Hu

    Citation: Clinical Epigenetics 2019 11:189

    Content type: Research

    Published on:

  2. Until today, adult and pediatric clinical trials investigating single-agent or combinatorial HDAC inhibitors including vorinostat in solid tumors have largely failed to demonstrate efficacy. These results may ...

    Authors: Cornelis M. van Tilburg, Till Milde, Ruth Witt, Jonas Ecker, Thomas Hielscher, Angelika Seitz, Jens-Peter Schenk, Juliane L. Buhl, Dennis Riehl, Michael C. Frühwald, Arnulf Pekrun, Claudia Rossig, Regina Wieland, Christian Flotho, Uwe Kordes, Bernd Gruhn…

    Citation: Clinical Epigenetics 2019 11:188

    Content type: Research

    Published on:

  3. The role of DNA methylation in aging has been widely studied. However, epigenetic mutations, here defined as aberrant methylation levels compared to the distribution in a population, are less understood. Hence...

    Authors: Yunzhang Wang, Robert Karlsson, Juulia Jylhävä, Åsa K. Hedman, Catarina Almqvist, Ida K. Karlsson, Nancy L. Pedersen, Malin Almgren and Sara Hägg

    Citation: Clinical Epigenetics 2019 11:187

    Content type: Research

    Published on:

  4. Emerging evidence indicates that dysregulation of microRNAs (miRNAs) contributes to cervical cancer (CC) tumorigenesis and development. Previous work showed that miR-484 which regulated the EMT process was obv...

    Authors: Yang Hu, Fuxia Wu, Yankun Liu, Qian Zhao and Hua Tang

    Citation: Clinical Epigenetics 2019 11:186

    Content type: Research

    Published on:

  5. Molecular signatures are being increasingly incorporated into cancer classification systems. DNA methylation-based central nervous system (CNS) tumor classification is being recognized as having the potential ...

    Authors: Shirin Karimi, Jeffrey A. Zuccato, Yasin Mamatjan, Sheila Mansouri, Suganth Suppiah, Farshad Nassiri, Phedias Diamandis, David G. Munoz, Kenneth D. Aldape and Gelareh Zadeh

    Citation: Clinical Epigenetics 2019 11:185

    Content type: Research

    Published on:

  6. Recent studies suggested that ZMYND10 is a potential tumor suppressor gene in multiple tumor types. However, the mechanism by which ZMYND10 inhibits breast cancer remains unclear. Here, we investigated the role a...

    Authors: Yan Wang, Liangying Dan, Qianqian Li, Lili Li, Lan Zhong, Bianfei Shao, Fang Yu, Sanxiu He, Shaorong Tian, Jin He, Qian Xiao, Thomas C. Putti, Xiaoqian He, Yixiao Feng, Yong Lin and Tingxiu Xiang

    Citation: Clinical Epigenetics 2019 11:184

    Content type: Research

    Published on:

  7. Cancer still is one of the leading causes of death and its death toll is predicted to rise further. We identified earlier the potential tumour suppressor zygote arrest 1 (ZAR1) to play a role in lung carcinoge...

    Authors: Verena Deutschmeyer, Janina Breuer, Sara K. Walesch, Anna M. Sokol, Johannes Graumann, Marek Bartkuhn, Thomas Boettger, Oliver Rossbach and Antje M. Richter

    Citation: Clinical Epigenetics 2019 11:182

    Content type: Research

    Published on:

  8. Obesity is a major worldwide threat to human health. Increasing evidence indicates that epigenetic modifications have a major impact on the natural history of this disorder. Ankyrin Repeat Domain 26 (Ankrd26) is ...

    Authors: Antonella Desiderio, Michele Longo, Luca Parrillo, Michele Campitelli, Giuseppe Cacace, Sonia de Simone, Rosa Spinelli, Federica Zatterale, Serena Cabaro, Pasquale Dolce, Pietro Formisano, Marco Milone, Claudia Miele, Francesco Beguinot and Gregory A. Raciti

    Citation: Clinical Epigenetics 2019 11:181

    Content type: Research

    Published on:

  9. Epigenetic mechanisms provide an interface between environmental factors and the genome and are influential in various diseases. These mechanisms, including DNA methylation, influence the regulation of develop...

    Authors: Ji Hyae Lim, Yu-Jung Kang, Bom Yi Lee, You Jung Han, Jin Hoon Chung, Moon Young Kim, Min Hyoung Kim, Jin Woo Kim, Youl-Hee Cho and Hyun Mee Ryu

    Citation: Clinical Epigenetics 2019 11:180

    Content type: Research

    Published on:

  10. Cisplatin-based chemotherapy (CBCT) is part of standard treatment of several cancers. In testicular cancer (TC) survivors, an increased risk of developing metabolic syndrome (MetS) is observed. In this epigeno...

    Authors: Cecilie Bucher-Johannessen, Christian M. Page, Trine B. Haugen, Marcin W. Wojewodzic, Sophie D. Fosså, Tom Grotmol, Hege S. Haugnes and Trine B. Rounge

    Citation: Clinical Epigenetics 2019 11:179

    Content type: Research

    Published on:

  11. Gingivo-buccal oral squamous cell carcinoma (OSCC-GB) is the most common cancer among men in India and is associated with high mortality. Although OSCC-GB is known to be quite different from tongue cancer in i...

    Authors: Debodipta Das, Sahana Ghosh, Arindam Maitra, Nidhan K. Biswas, Chinmay K. Panda, Bidyut Roy, Rajiv Sarin and Partha P. Majumder

    Citation: Clinical Epigenetics 2019 11:178

    Content type: Research

    Published on:

  12. In order to gain insight into the contribution of DNA methylation to disease progression of chronic lymphocytic leukemia (CLL), using 450K Illumina arrays, we determined the DNA methylation profiles in paired ...

    Authors: Maria Tsagiopoulou, Nikos Papakonstantinou, Theodoros Moysiadis, Larry Mansouri, Viktor Ljungström, Martí Duran-Ferrer, Andigoni Malousi, Ana C. Queirós, Karla Plevova, Sujata Bhoi, Panagoula Kollia, David Oscier, Achilles Anagnostopoulos, Livio Trentin, Matthias Ritgen, Sarka Pospisilova…

    Citation: Clinical Epigenetics 2019 11:177

    Content type: Research

    Published on:

  13. Adolescence is a period characterized by major biological development, which may be associated with changes in DNA methylation (DNA-M). However, it is unknown to what extent DNA-M varies from pre- to post-adol...

    Authors: Luhang Han, Hongmei Zhang, Akhilesh Kaushal, Faisal I. Rezwan, Latha Kadalayil, Wilfried Karmaus, A. John Henderson, Caroline L. Relton, Susan Ring, S. Hasan Arshad, Susan L. Ewart and John W. Holloway

    Citation: Clinical Epigenetics 2019 11:176

    Content type: Research

    Published on:

  14. Lung (LC), prostate (PCa) and colorectal (CRC) cancers are the most incident in males worldwide. Despite recent advances, optimal population-based cancer screening methods remain an unmet need. Due to its earl...

    Authors: Vera Constâncio, Sandra P. Nunes, Catarina Moreira-Barbosa, Rui Freitas, Jorge Oliveira, Inês Pousa, Júlio Oliveira, Marta Soares, Carlos Gonçalves Dias, Teresa Dias, Luís Antunes, Rui Henrique and Carmen Jerónimo

    Citation: Clinical Epigenetics 2019 11:175

    Content type: Research

    Published on:

  15. The flexibility of the epigenome has generated an enticing argument to explore its reversion through pharmacological treatments as a strategy to ameliorate disease phenotypes. All three families of epigenetic ...

    Authors: A. Ganesan, Paola B. Arimondo, Marianne G. Rots, Carmen Jeronimo and María Berdasco

    Citation: Clinical Epigenetics 2019 11:174

    Content type: Review

    Published on:

  16. Glioblastoma (GBM) is the most lethal and aggressive malignant primary brain tumor in adults. After surgical resection of the tumor, the patient typically should be subjected to chemotherapy (temozolomide, TMZ...

    Authors: Giulia Stazi, Ludovica Taglieri, Alice Nicolai, Annalisa Romanelli, Rossella Fioravanti, Stefania Morrone, Manuela Sabatino, Rino Ragno, Samanta Taurone, Marcella Nebbioso, Raffaella Carletti, Marco Artico, Sergio Valente, Susanna Scarpa and Antonello Mai

    Citation: Clinical Epigenetics 2019 11:173

    Content type: Research

    Published on:

  17. There is solid evidence that obesity induces the acceleration of liver epigenetic aging. However, unlike easily accessible blood or subcutaneous adipose tissue, little is known about the impact of obesity on e...

    Authors: Juan de Toro-Martín, Frédéric Guénard, André Tchernof, Frédéric-Simon Hould, Stéfane Lebel, François Julien, Simon Marceau and Marie-Claude Vohl

    Citation: Clinical Epigenetics 2019 11:172

    Content type: Research

    Published on:

  18. Constitutional MLH1 methylation (epimutation) is a rare cause of Lynch syndrome. Low-level methylation (≤ 10%) has occasionally been described. This study aimed to identify low-level constitutional MLH1 epimutati...

    Authors: Estela Dámaso, Júlia Canet-Hermida, Gardenia Vargas-Parra, Àngela Velasco, Fátima Marín, Esther Darder, Jesús del Valle, Anna Fernández, Àngel Izquierdo, Gemma Mateu, Glòria Oliveras, Carmen Escribano, Virgínia Piñol, Hugo-Ikuo Uchima, José Luis Soto, Megan Hitchins…

    Citation: Clinical Epigenetics 2019 11:171

    Content type: Short report

    Published on:

  19. Endometrial cancer is a common gynecologic cancer. Noninvasive molecular biomarkers for triage of high-risk patients for invasive procedures are needed. Based on the success of cytological Pap smear screening,...

    Authors: Phui-Ly Liew, Rui-Lan Huang, Tzu-I Wu, Chi-Chun Liao, Chien-Wen Chen, Po-Hsuan Su, Hui-Chen Wang, Yu-Chun Weng and Hung-Cheng Lai

    Citation: Clinical Epigenetics 2019 11:170

    Content type: Research

    Published on:

  20. Perinatal depressive symptoms have been linked to adverse maternal and infant health outcomes. The etiology associated with perinatal depressive psychopathology is poorly understood, but accumulating evidence ...

    Authors: Dana M. Lapato, Roxann Roberson-Nay, Robert M. Kirkpatrick, Bradley T. Webb, Timothy P. York and Patricia A. Kinser

    Citation: Clinical Epigenetics 2019 11:169

    Content type: Research

    Published on:

  21. An epigenetic field of cancer susceptibility exists for prostate cancer (PC) that gives rise to multifocal disease in the peripheral prostate. In previous work, genome-wide DNA methylation profiling identified...

    Authors: Bing Yang, Tyler Etheridge, Johnathon McCormick, Adam Schultz, Tariq A. Khemees, Nathan Damaschke, Glen Leverson, Kaitlin Woo, Geoffrey A. Sonn, Eric A. Klein, Mike Fumo, Wei Huang and David F. Jarrard

    Citation: Clinical Epigenetics 2019 11:168

    Content type: Research

    Published on:

  22. Glial cells in the central nervous system play a key role in neuroinflammation and subsequent central sensitization to pain. They are therefore involved in the development of persistent pain. One of the main s...

    Authors: Dario Kringel, Mari A. Kaunisto, Eija Kalso and Jörn Lötsch

    Citation: Clinical Epigenetics 2019 11:167

    Content type: Research

    Published on:

  23. Ovarian cancer (OC) is the most lethal gynecological cancer, worldwide, largely due to its vague and nonspecific early stage symptoms, resulting in most tumors being found at advanced stages. Moreover, due to ...

    Authors: Tzu-I Wu, Rui-Lan Huang, Po-Hsuan Su, Shih-Peng Mao, Chen-Hsuan Wu and Hung-Cheng Lai

    Citation: Clinical Epigenetics 2019 11:166

    Content type: Research

    Published on:

  24. Euchromatic histone-lysine-N-methyltransferases 1 and 2 (EHMT1/2, aka GLP/G9A) catalyze dimethylation of histone H3 lysine 9 (H3K9me2) and have roles in epigenetic silencing of gene expression. EHMT1/2 also have ...

    Authors: Zachary L. Watson, Tomomi M. Yamamoto, Alexandra McMellen, Hyunmin Kim, Connor J. Hughes, Lindsay J. Wheeler, Miriam D. Post, Kian Behbakht and Benjamin G. Bitler

    Citation: Clinical Epigenetics 2019 11:165

    Content type: Research

    Published on:

  25. Late-onset Alzheimer’s disease (AD) is a complex multifactorial affliction, the pathogenesis of which is thought to involve gene-environment interactions that might be captured in the epigenome. The present st...

    Authors: Roy Lardenoije, Janou A. Y. Roubroeks, Ehsan Pishva, Markus Leber, Holger Wagner, Artemis Iatrou, Adam R. Smith, Rebecca G. Smith, Lars M. T. Eijssen, Luca Kleineidam, Amit Kawalia, Per Hoffmann, Tobias Luck, Steffi Riedel-Heller, Frank Jessen, Wolfgang Maier…

    Citation: Clinical Epigenetics 2019 11:164

    Content type: Research

    Published on:

  26. Recently, an alcohol predictor was developed using DNA methylation at 144 CpG sites (DNAm-Alc) as a biomarker for improved clinical or epidemiologic assessment of alcohol-related ill health. We validate the pe...

    Authors: Paul Darius Yousefi, Rebecca Richmond, Ryan Langdon, Andrew Ness, Chunyu Liu, Daniel Levy, Caroline Relton, Matthew Suderman and Luisa Zuccolo

    Citation: Clinical Epigenetics 2019 11:163

    Content type: Research

    Published on:

  27. Over the last several decades, the average age of first-time mothers has risen steadily. With increasing maternal age comes a decrease in fertility, which in turn has led to an increase in the use of assisted ...

    Authors: Audrey J. Kindsfather, Megan A. Czekalski, Catherine A. Pressimone, Margaret P. Erisman and Mellissa R. W. Mann

    Citation: Clinical Epigenetics 2019 11:162

    Content type: Research

    Published on:

  28. The T cell immunoglobulin and mucin-domain containing-3 receptor TIM-3 (also known as hepatitis A virus cellular receptor 2, encoded by HAVCR2) and its ligand galectin 9 (LGALS9) are promising targets for immune ...

    Authors: Tobias A. W. Holderried, Luka de Vos, Emma Grace Bawden, Timo J. Vogt, Joern Dietrich, Romina Zarbl, Friedrich Bootz, Glen Kristiansen, Peter Brossart, Jennifer Landsberg and Dimo Dietrich

    Citation: Clinical Epigenetics 2019 11:161

    Content type: Research

    Published on:

  29. The metabolic syndrome (MetS) is a collection of metabolic disturbances that can lead to various cardiovascular diseases. Previous studies have shown a more adverse metabolic risk profile is associated with mo...

    Authors: Drew R. Nannini, Brian T. Joyce, Yinan Zheng, Tao Gao, Lei Liu, Grace Yoon, Tianxiao Huan, Jiantao Ma, David R. Jacobs Jr, John T. Wilkins, Jim Ren, Kai Zhang, Sadiya S. Khan, Norrina Bai Allen, Steve Horvath, Donald M. Lloyd-Jones…

    Citation: Clinical Epigenetics 2019 11:160

    Content type: Research

    Published on:

  30. Diuron is an environmental component listed as a likely human carcinogen. Several other studies report that diuron can be oncogenic for bladder, urothelial, skin, and mammary cells. No study mentions the putat...

    Authors: Joséphine Briand, Arulraj Nadaradjane, Gwenola Bougras-Cartron, Christophe Olivier, François M. Vallette and Pierre-François Cartron

    Citation: Clinical Epigenetics 2019 11:159

    Content type: Research

    Published on:

  31. Early detection plays an essential role to reduce colorectal cancer (CRC) mortality. While current screening methods suffer from poor compliance, liquid biopsy-based strategies for cancer detection is rapidly ...

    Authors: Sarah Østrup Jensen, Nadia Øgaard, Mai-Britt Worm Ørntoft, Mads Heilskov Rasmussen, Jesper Bertram Bramsen, Helle Kristensen, Peter Mouritzen, Mogens Rørbæk Madsen, Anders Husted Madsen, Kåre Gotschalck Sunesen, Lene Hjerrild Iversen, Søren Laurberg, Ib Jarle Christensen, Hans Jørgen Nielsen and Claus Lindbjerg Andersen

    Citation: Clinical Epigenetics 2019 11:158

    Content type: Research

    Published on:

  32. Recently, it was shown that the epigenetic age of non-small cell lung cancer (NSCLC) tissues is different from the chronological age of patients. Here, we demonstrate that Regucalcin and Survivin, molecules wh...

    Authors: Dörte Nitschkowski, Sebastian Marwitz, Sousana A. Kotanidou, Martin Reck, Christian Kugler, Klaus F. Rabe, Ole Ammerpohl and Torsten Goldmann

    Citation: Clinical Epigenetics 2019 11:157

    Content type: Letter to the Editor

    Published on:

  33. SETD1B is a component of a histone methyltransferase complex that specifically methylates Lys-4 of histone H3 (H3K4) and is responsible for the epigenetic control of chromatin structure and gene expression. De...

    Authors: I. M. Krzyzewska, S. M. Maas, P. Henneman, K. v. d. Lip, A. Venema, K. Baranano, A. Chassevent, E. Aref-Eshghi, A. J. van Essen, T. Fukuda, H. Ikeda, M. Jacquemont, H.-G. Kim, A. Labalme, S. M. E. Lewis, G. Lesca…

    Citation: Clinical Epigenetics 2019 11:156

    Content type: Research

    Published on:

  34. The glucocorticoid receptor (NR3C1, GR) is frequently downregulated in breast tumors, and evidence suggests it acts as a tumor suppressor in estrogen receptor-positive (ER+) breast cancer. We previously found tha...

    Authors: Hilary Snider, Brithica Villavarajan, Yingwei Peng, Lois E. Shepherd, Andrew C. Robinson and Christopher R. Mueller

    Citation: Clinical Epigenetics 2019 11:155

    Content type: Research

    Published on:

  35. Aberrant DNA methylation is involved in gastric carcinogenesis and may serve as a useful biomarker in the diagnosis and detection of gastric cancer (GC) recurrence.

    Authors: Wen-Liang Fang, Ming-Huang Chen, Kuo-Hung Huang, Shih-Ching Chang, Chien-Hsing Lin, Yee Chao, Su-Shun Lo, Anna Fen-Yau Li, Chew-Wun Wu and Yi-Ming Shyr

    Citation: Clinical Epigenetics 2019 11:154

    Content type: Research

    Published on:

  36. One major reason of the high mortality of epithelial ovarian cancer (EOC) is due to platinum-based chemotherapy resistance. Aberrant DNA methylation may be a potential mechanism underlying the development of p...

    Authors: Hua Tian, Li Yan, Li Xiao-fei, Sun Hai-yan, Chen Juan and Kang Shan

    Citation: Clinical Epigenetics 2019 11:153

    Content type: Research

    Published on:

  37. Men often undergo repeat prostate biopsies because of suspicion of missed cancer. We assessed if (i) methylation of selected genes in prostate tissue vary with aging and (ii) methylation alterations in repeat ...

    Authors: Valentina Fiano, Daniela Zugna, Chiara Grasso, Morena Trevisan, Luisa Delsedime, Luca Molinaro, Paola Cassoni, Mauro Papotti, Franco Merletti, Olof Akre, Andreas Pettersson, Laura De Marco and Lorenzo Richiardi

    Citation: Clinical Epigenetics 2019 11:152

    Content type: Research

    Published on:

  38. Platelet-endothelial aggregation receptor 1 (PEAR-1) is a transmembrane receptor involved in platelet activation and megakaryopoiesis whose expression is driven by DNA methylation. PEAR1 variants were associated ...

    Authors: Benedetta Izzi, Francesco Gianfagna, Wen-Yi Yang, Katrien Cludts, Amalia De Curtis, Peter Verhamme, Augusto Di Castelnuovo, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Jan A. Staessen, Marc F. Hoylaerts and Licia Iacoviello

    Citation: Clinical Epigenetics 2019 11:151

    Content type: Research

    Published on:

  39. It is widely accepted that genomic instability is associated with several mechanisms involving oxidative stress, which can increase the rate of DNA breaks. Such factors include smoking, impairments in body com...

    Authors: Alejandra Locken-Castilla, Elda Leonor Pacheco-Pantoja, Fátima Rodríguez-Brito, Sherlin May-Kim, Victor López-Rivas and Angel Ceballos-Cruz

    Citation: Clinical Epigenetics 2019 11:150

    Content type: Research

    Published on:

  40. Programmed epigenetic modifications occurring at early postnatal brain developmental stages may have a long-lasting impact on brain function and complex behavior throughout life. Notably, it is now emerging th...

    Authors: Mariella Cuomo, Simona Keller, Daniela Punzo, Tommaso Nuzzo, Ornella Affinito, Lorena Coretti, Massimo Carella, Valeria de Rosa, Ermanno Florio, Francesca Boscia, Vittorio Enrico Avvedimento, Sergio Cocozza, Francesco Errico, Alessandro Usiello and Lorenzo Chiariotti

    Citation: Clinical Epigenetics 2019 11:149

    Content type: Research

    Published on:

  41. The clinical course of prostate cancer (PCa) is highly variable, demanding an individualized approach to therapy. Overtreatment of indolent PCa cases, which likely do not progress to aggressive stages, may be ...

    Authors: Reka Toth, Heiko Schiffmann, Claudia Hube-Magg, Franziska Büscheck, Doris Höflmayer, Sören Weidemann, Patrick Lebok, Christoph Fraune, Sarah Minner, Thorsten Schlomm, Guido Sauter, Christoph Plass, Yassen Assenov, Ronald Simon, Jan Meiners and Clarissa Gerhäuser

    Citation: Clinical Epigenetics 2019 11:148

    Content type: Research

    Published on:

  42. Current diagnostic and prognostic tools for prostate cancer (PC) are suboptimal, resulting in overdiagnosis and overtreatment of clinically insignificant tumors. Thus, to improve the management of PC, novel bi...

    Authors: Maibritt Nørgaard, Christa Haldrup, Marianne Trier Bjerre, Søren Høyer, Benedicte Ulhøi, Michael Borre and Karina D. Sørensen

    Citation: Clinical Epigenetics 2019 11:147

    Content type: Research

    Published on:

  43. Psychiatric symptomatology during late childhood and early adolescence tends to persist later in life. In the present longitudinal study, we aimed to identify changes in genome-wide DNA methylation patterns th...

    Authors: Leticia M. Spindola, Marcos L. Santoro, Pedro M. Pan, Vanessa K. Ota, Gabriela Xavier, Carolina M. Carvalho, Fernanda Talarico, Patrick Sleiman, Michael March, Renata Pellegrino, Elisa Brietzke, Rodrigo Grassi-Oliveira, Jair J. Mari, Ary Gadelha, Euripedes C. Miguel, Luis A. Rohde…

    Citation: Clinical Epigenetics 2019 11:146

    Content type: Research

    Published on:

  44. The two most common repetitive elements (REs) in humans, long interspersed nuclear element-1 (LINE-1) and Alu element (Alu), have been linked to various cancers. Hepatitis C virus (HCV) may cause hepatocellula...

    Authors: Yinan Zheng, Ryan A. Hlady, Brian T. Joyce, Keith D. Robertson, Chunyan He, Drew R. Nannini, Warren A. Kibbe, Chad J. Achenbach, Robert L. Murphy, Lewis R. Roberts and Lifang Hou

    Citation: Clinical Epigenetics 2019 11:145

    Content type: Research

    Published on:

  45. After publication of the original article [1], authors have requested to add a ‘J’ as middle name for Richard Gilbertson. Hence, full name should be Richard J Gilbertson.

    Authors: Malgorzata Pienkowska, Sanaa Choufani, Andrei L. Turinsky, Tanya Guha, Diana M. Merino, Ana Novokmet, Michael Brudno, Rosanna Weksberg, Adam Shlien, Cynthia Hawkins, Eric Bouffet, Uri Tabori, Richard J. Gilbertson, Jonathan L. Finlay, Nada Jabado, Christian Thomas…

    Citation: Clinical Epigenetics 2019 11:144

    Content type: Correction

    Published on:

    The original article was published in Clinical Epigenetics 2019 11:117

  46. Patients with haematological malignancies are often vitamin C deficient, and vitamin C is essential for the TET-induced conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), the first step in...

    Authors: Linn Gillberg, Andreas D. Ørskov, Ammar Nasif, Hitoshi Ohtani, Zachary Madaj, Jakob W. Hansen, Nicolas Rapin, Johanne B. Mogensen, Minmin Liu, Inge H. Dufva, Jens Lykkesfeldt, Petra Hajkova, Peter A. Jones and Kirsten Grønbæk

    Citation: Clinical Epigenetics 2019 11:143

    Content type: Research

    Published on:

  47. Epigenome-wide association studies using DNA methylation have the potential to uncover novel biomarkers and mechanisms of cardiovascular disease (CVD) risk. However, the direction of causation for these associ...

    Authors: Kenneth Westerman, Paola Sebastiani, Paul Jacques, Simin Liu, Dawn DeMeo and José M. Ordovás

    Citation: Clinical Epigenetics 2019 11:142

    Content type: Research

    Published on:

  48. The epigenetic machinery is frequently altered in acute myeloid leukemia. Focusing on cytogenetically normal (CN) AML, we previously described an abnormal H3K27me3 enrichment covering 70 kb on the HIST1 cluster (...

    Authors: Sylvain Garciaz, Lia N’guyen Dasi, Pascal Finetti, Christine Chevalier, Julien Vernerey, Mathilde Poplineau, Nadine Platet, Stéphane Audebert, Matthieu Pophillat, Luc Camoin, François Bertucci, Boris Calmels, Christian Récher, Daniel Birnbaum, Christian Chabannon, Norbert Vey…

    Citation: Clinical Epigenetics 2019 11:141

    Content type: Research

    Published on:

  49. Vigilant management of women with high-risk human papillomavirus (hrHPV) is necessary in cancer screening programs. To this end, we evaluated the performance of S5 (targeting DNA methylation in HPV16, HPV18, H...

    Authors: Rubí Hernández-López, Attila T. Lorincz, Leticia Torres-Ibarra, Caroline Reuter, Dorota Scibior-Bentkowska, Rhian Warman, Belinda Nedjai, Indira Mendiola-Pastrana, Leith León-Maldonado, Berenice Rivera-Paredez, Paula Ramírez-Palacios, Eduardo Lazcano-Ponce, Jack Cuzick and Jorge Salmerón

    Citation: Clinical Epigenetics 2019 11:140

    Content type: Research

    Published on: