Table 2 miRNAs related to diabetic cardiomyopathy

miR-320

Mouse

Up

Hyperlipidemia and hyperglycemia

cd36

[95]

miR-207

Mouse

Up

Autophagy

lamp2

[131]

miR-30d

Rat

Up

Pyroptosis, inflammation and apoptosis

foxo3a

[132]

Autophagy

klf9/vegfa

[133]

miR-223

Rat

Up

Inflammasome activation, fibrosis, and apoptosis

–

[134]

Mouse

Up

Glucose metabolism

glut4

[135]

miR-29

Mouse

Up

Fibrosis

–

[136]

miR-150

–

Up

Inflammation and fibrosis

smad7

[137]

miR-451

Mouse

Up

Lipid accumulation

cab39

[138]

miR-195

Mouse

Up

Apoptosis and oxidative stress

sirt1

[139]

miR-503

Rat

Up

Oxidative stress and apoptosis

nrf2

[140]

miR-326-3p

Mouse

Up

Metabolism and mitochondrial dysfunction

rictor

[141]

miR-30c

Mouse, rat

Down

Autophagy

beclin1

[142]

Down

Hypertrophy and apoptosis

p53, p21

[143]

Down

Hypertrophy

cdc42, pak1

[144]

Down

Oxidative stress and apoptosis

pgc-1β

[145]

miR-133a

Mouse

Down

Fibrosis

erk1/2, smad-2

[146]

miR-200b

Mouse

Down

Cardiac fibrosis

p300

[147]

miR-222

Mouse

Down

Cardiac fibrosis

β-catenin

[148]

miR-551b-5p

Rat

Down

Autophagy

Protocadherin 17

[110]

miR-1

Rat

Down

Oxidative stress

Junctin

[149]

miR-9

/

Down

Pyroptosis and inflammation

elavl1 casp-1

[150]

miR-203

Mouse

Down

Oxidative stress, hypertrophy, fibrosis, and apoptosis

pik3ca

[151]

miR-21

Mouse

Down

Oxidative stress, hypertrophy, fibrosis, and apoptosis

Gelsolin, ppara, dusp8, spry1, ar

[152]

miR-22

Mouse

Down

Oxidative stress and apoptosis

sirt1

[153]

miR-373

Mouse

Down

Hypertrophy

mef2c

[154]

miR-15

Mouse

Down

Fibrosis

tgfbr1

[155]

miR141

Mouse

Down

Inflammation and fibrosis

nlrp3 and tgf-β1

[156]

miR146a

Mouse

Down

Inflammation and fibrosis

irak and traf6

[157]