Table 1 lncRNAs associated with diabetic cardiomyopathy

DCRF

Rat

Up

Autophagy and myocardial fibrosis

Sponging mir-551b-5p to increase pcdh17 expression

[110]

DACH1

Mouse

Up

Mitochondria, oxidative stress, cell apoptosis, fibrosis and hypertrophy

Binding to sirtuin3 and promoting sirtuin3 degradation

[111]

TINCR

Rat

Up

Pyroptosis

Promoting the expression of nlrp3 by sustaining mrna stability

[78]

Kcnq1ot1

Mouse

Up

Fibrosis and pyroptosis

Regulate the expression of caspase-1 by sponging mir-214-3p

[82]

Mouse

Up

Apoptosis and inflammation

Sponging mir-181a-5p and increasing pdcd4 expression

[112]

ZNF593-AS

Mouse

Down

Apoptosis and inflammation

Interacted with irf3 and suppressing fatty acid-induced phosphorylation

[113]

MALAT1

Rats

Up

pyroptosis and fibrosis

–

[79]

Rats

Up

inflammation

–

[114]

Rat

Up

Cell scorch death

Inhibiting nlrp3 expression

[115]

Mouse

Up

Apoptosis

Recruiting ezh2 to the mir-22 promoter region

[116]

Rat

Up

apoptosis

/

[117]

Airn

Mouse

Down

Cardiac fibrosis

Binding to imp2 and preventing its degradation

[118]

ZFAS1

Mouse

Up

Ferroptosis and apoptosis

Sponges miR-150-5p to inhibit CCND2 expression

[119]

H19

Rat

Up

Oxidative stress, inflammation and apoptosis

Increasing miR-675 expression and further reduce VDAC1

[87]

Rat

Up

Apoptosis

Inducing miR-29c expression and promoting MAPK13

[88]

GAS5

Mouse

Down

Inflammation and pyroptosis

Sponging miR-34b-3p and suppressing NLRP3 inflammasome activation-mediated pyroptosis

[81]

–

Down

Apoptosis

Sponging miR-320-3p to modulate the apoptosis of NMC

[120]

Rat

Down

Autophagy

Sponging miR-221-3p to upregulate p27

[121]

Rat

Down

Proliferation and apoptosis

Targeting miR-138 to down-regulate CYP11B2 and attenuating cardiomyocyte injury

[122]

HOTAIR

–

Down

Pyroptosis and inflammation

Recruiting FUS to regulate SIRT3 expression

[85]

Mouse

Down

Oxidative stress and inflammation

Sponging miR-34a to regulate SIRT1

[86]

TINCR

–

Down

Apoptosis

–

[123]

Crnde

Mouse

Up

Fibrosis

Binding to Smad3 to attenuate cardiac fibrosis

[84]

NEAT1

Rat

Down

Apoptosis

Regulating Nrf2 expression by sponging miR-23a-3p

[124]

MIAT

Rat

Up

Apoptosis

Sponging miR-22-3p to upregulate DAPK2

[125]

NORAD

Mouse

Up

Fibrosis and inflammation

Sponging to adsorb miR-125a-3p, and regulating Fyn

[126]

AK081284

Mouse

Up

Fibrosis

Promoted the production of collagen and TGFβ1

[83]

ANRIL

Rat

Up

Oxidative stress, apoptosis, inflammation, fibrosis

–

[127]

NONRATT007560.2

–

Up

Oxidative stress and apoptosis

–

[128]

MEG3

–

Up

Apoptosis

Sponging microRNA-145 to up-regulating the expression of PDCD4

[129]

PVT1

–

Up

Apoptosis

Sponge miR-23a-3p to increase CASP10 expression

[130]