Fig. 7

The establishment of cervical cancer organoids and their response to the treatment of selenium and GSK-J4. A The immunohistochemical analysis evaluating the expression of histone demethylases UTX (KDM6A) and JMJD3 (KDM6B) in cervical cancer and normal cervical tissues. The left column displays images taken under 10 × magnification, with a scale bar of 200 μm, while the right column shows images taken under 40 × magnification, with a scale bar of 50 μm. B A schematic of cervical cancer organoids generating. C shows representative images of cervical cancer organoids. D The effects of different concentrations of selenium dioxide and E GSK-J4 on the viability of cervical cancer organoids, as assessed using the CCK8 assay. F The impact of different concentrations of selenium dioxide on the viability of three-dimensional bio-printed cervical cancer models. **p < 0.01; ***p < 0.001; ****p < 0.0001; ns p > 0.05