Fig. 7

DNMT1 and SOS1 as direct targets of miR-152-3p in the H460-derived LCSLCs A Schematic representation of the binding sites of miR-152-3p and DNMT1 3'UTR of wild-type (wt) and mutant (mut) clones cloned into the luciferase reporter arrangement of pLUC control; B and C Relative luciferase activity in H460-derived LCSLCs was determined after co-transfection of the DNMT1 3'UTR wild-type or mutant plasmid with a miR-152-3p mimic or negative control. D Schematic representation of the binding sites of miR-152-3p and SOS1 3'UTR of wild-type (wt) and mutant (mut) clones cloned into the luciferase reporter arrangement of the pLUC control; E and F Relative luciferase activity in H460-derived LCSLCs was determined after co-transfection of the SOS1 3'UTR wild-type or mutant plasmid with a miR-152-3p mimic or negative control. *p < 0.05 vs. NC