Fig. 1

Design and analyses of the study. A Participants were selected according to their neglect/control parenting behavior. B Methylation values were obtained from mothers’ and children’s saliva samples. C Pairs were made by combinations of the mother–own child (familial pair) or mother–random child (random pair) in neglect and control dyads. D A mother–child Methylation Similarity Index (MSI) was obtained by correlating mother and child methylation values for each pair across the CpGs of the corresponding region. E Linear regression analyses against covariates were implemented at the whole epigenome and at specific genes for familial and random pairs