From: Abnormal DNA methylation within HPA-axis genes years after paediatric critical illness
Gene | CpG site | Gene sectiona,b | Former PICU patients versus healthy children | Former PICU patients: GC versus No CG treatment | |||||
---|---|---|---|---|---|---|---|---|---|
Methylation statusc | Log Fold Change [Confidence Interval]d | Absolute mean differencee | p valuef | p valuef | |||||
Pt vs Ctrlg | Int. sex | Int. age | |||||||
CRHR1 | cg15607306 | Body | Hypo | − 0.066 [− 0.108 to − 0.023] | 0.004 | 0.049 | 0.87 | 0.91 | 0.77 |
POMC | cg09672383 | 5’UTR | Hypo | − 0.082 [− 0.135 to − 0.03] | 0.018 | 0.049 | 0.70 | 0.62 | 0.11 |
MC2R | cg26344168 | Body | Hypo | − 0.07 [− 0.113 to − 0.027] | 0.011 | 0.049 | 0.44 | 0.52 | 0.83 |
NR3C1 | cg26720913 | 5’UTR/1stExon | Hypo | − 0.163 [− 0.265 to − 0.062] | 0.037 | 0.049 | 0.46 | 0.27 | 0.14 |
cg01967637 | Promoter/5’UTR/1stExon | Hyper | 0.1 [0.037 – 0.163] | 0.02 | 0.049 | 0.33 | 0.84 | 0.080 | |
cg15910486 | Promoter/5’UTR | Hyper | 0.09 [0.039 – 0.141] | 0.02 | 0.033 | 0.64 | 0.87 | 0.62 | |
FKBP5 | cg23416081 | 5’UTR | Hypo | − 0.292 [− 0.432 to − 0.152] | 0.055 | 0.0052 | 0.54 | 0.48 | 0.017 |
cg15929276 | 5’UTR | Hypo | − 0.252 [− 0.397 to − 0.107] | 0.051 | 0.037 | 0.36 | 0.83 | 0.0045 | |
cg03591753 | 5’UTR | Hypo | − 0.132 [− 0.176 to − 0.088] | 0.031 | < 0.00001 | 0.58 | 0.0060 | 0.26 | |
cg20813374 | Promoter/5’UTR | Hypo | − 0.126 [− 0.183 to − 0.07] | 0.02 | 0.0019 | 0.91 | 0.055 | 0.60 | |
cg03546163 | 5’UTR | Hypo | − 0.178 [− 0.248 to − 0.108] | 0.029 | 0.00012 | 0.97 | 0.00063 | 0.92 | |
cg01839003 | 5’UTR | Hypo | − 0.077 [− 0.125 to − 0.029] | 0.007 | 0.049 | 0.37 | 0.11 | 0.036 | |
cg22363520 | Body | Hypo | − 0.253 [− 0.338 to − 0.167] | 0.017 | < 0.00001 | 0.83 | 0.10 | 0.068 | |
HSD11B1 | cg06571187 | Promoter/5’UTR | Hypo | − 0.108 [− 0.177 to − 0.039] | 0.017 | 0.049 | 0.94 | 0.027 | 0.18 |
cg14139038 | Promoter/5’UTR | Hypo | − 0.078 [− 0.118 to − 0.039] | 0.01 | 0.0098 | 0.42 | 0.0020 | 0.49 | |
SRD5A1 | cg22911074 | Promoter | Hyper | 0.081 [0.031 – 0.13] | 0.01 | 0.049 | 0.72 | 0.90 | 0.018 |
AKR1D1 | cg02118020 | Body | Hyper | 0.188 [0.067 – 0.31] | 0.047 | 0.049 | 0.25 | 0.25 | 0.017 |
cg05082563 | Body | Hypo | − 0.127 [− 0.208 to − 0.046] | 0.024 | 0.049 | 0.81 | 0.67 | 0.11 | |
cg27250318 | Body | Hypo | − 0.181 [− 0.29 to − 0.071] | 0.033 | 0.049 | 0.70 | 0.42 | 0.16 | |
cg09373725 | Body | Hypo | − 0.098 [− 0.159 to − 0.038] | 0.015 | 0.049 | 0.82 | 0.22 | 0.45 | |
DUSP1 | cg00593243 | Body | Hyper | 0.184 [0.071 – 0.297] | 0.042 | 0.049 | 0.28 | 0.34 | 0.11 |
TSC22D3 | cg26954928 | Body | Hypo | − 0.099 [− 0.161 to − 0.037] | 0.002 | 0.049 | 0.38 | 0.061 | 0.41 |
cg11907074 | Promoter/Body | Hyper | 0.114 [0.052 – 0.176] | 0.008 | 0.020 | 0.86 | 0.56 | 0.69 | |
TNF | cg10650821 | 1stExon | Hypo | − 0.059 [− 0.09 to − 0.029] | 0.014 | 0.012 | 0.82 | 0.45 | 0.17 |
cg26729380 | 1stExon | Hypo | − 0.052 [− 0.085 to − 0.019] | 0.01 | 0.049 | 0.75 | 0.80 | 0.66 | |
cg08553327 | 1stExon | Hypo | − 0.062 [− 0.099 to − 0.025] | 0.01 | 0.049 | 0.89 | 0.49 | 0.28 |