CpG | Gene | Total effect | Direct effect (DE) | Mediational effect (ME) | ||||
---|---|---|---|---|---|---|---|---|
β (95% CI) | P value | β (95% CI) | P value | β (95% CI) | P value | Mediation proportion | ||
Asthma severity association | Â | Â | Â | Â | Â | Â | Â | Â |
cg17945560 | TINAGL1 | 0.34 (0.06, 0.59) | 0.016 | 0.076 (− 0.15, 0.28) | 0.52 | 0.26 (0.09, 0.44) | 2E−16 | 77.5 |
cg01975495 | SERPINE1 | 0.69 (0.36, 0.99) | 2E−16 | 0.57 (0.24, 0.88) | 2E−16 | 0.12 (0.03, 0.25) | 0.004 | 17.3 |
cg14015211 | TLR5 | 0.314 (0.21, 0.43) | 2E−16 | 0.21 (0.07, 0.35) | 0.008 | 0.106 (0.04, 0.191) | 0.004 | 33.77 |
cg26639146 | CD9 | − 0.29 (− 0.5, − 0.06) | 0.016 | − 0.18 (− 0.38, 0.09) | 0.17 | − 0.10 (− 0.25, − 0.031) | 0.002 | 36.24 |
cg10290200 | FLNC | − 0.20 (− 0.3, − 0.1) | 2E−16 | − 0.15 (− 0.26, − 0.03) | 0.006 | − 0.05 (− 0.11, 01) | 0.06 | 26.69 |
cg25477769 | HNF1A | 0.57 (0.203, 0.93) | 0.002 | 0.39 (− 0.02, 0.82) | 0.068 | 0.18 (− 0.02, 0.391) | 0.08 | 31.18 |
cg21385480 | LRIG1 | 0.41 (0.281, 0.55) | 2E−16 | 0.3 (0.13, 0.45) | 2E−16 | 0.12 (0.03, 0.221) | 0.002 | 27.99 |
cg10528482 | SLC9A3 | 0.28 (0.183, 0.38) | 2E−16 | 0.2 (0.08, 0.31) | 2E−16 | 0.08 (0.02, 0.141) | 0.002 | 27.97 |
Lung function association | Â | Â | Â | Â | Â | Â | Â | Â |
g17945560 | TINAGL1 | − 0.27 (− 0.53, 0.01) | 0.06 | − 0.11 (− 0.36, 0.13) | 0.07 | − 0.17 (− 0.27, − 0.06) | 2E−16 | 61.2 |
cg01975495 | SERPINE1 | − 0.61 (− 0.84, − 0.38) | 2E−16 | − 0.55 (− 0.76, − 0.32) | 2E−16 | − 0.06 (− 0.15, 0.01) | 0.13 | 9.08 |
cg14015211 | TLR5 | − 0.41 (− 0.56, − 0.27) | 2E−16 | − 0.27 (− 0.43, − 0.12) | 2E−16 | − 0.14 (− 0.26, − 0.03) | 0.022 | 34.78 |
cg26639146 | CD9 | 0.34 (0.018–0.63) | 0.046 | 0.25 (− 0.18, 0.55) | 0.218 | 0.09 (0.003, 0.33) | 0.034 | 25.44 |
cg10290200 | FLNC | 0.22 (0.08–0.36) | 0.006 | 0.13 (− 0.04, 0.29) | 0.154 | 0.09 (0.004, 0.17) | 0.036 | 42.72 |
cg25477769 | HNF1A | − 0.65 (− 1.18, − 0.11) | 0.028 | − 0.47 (− 1.07, 0.16) | 0.162 | − 0.18 (− 0.43, 0.05) | 0.124 | 27.8 |
cg21385480 | LRIG1 | − 0.37 (− 0.58, − 0.13) | 0.002 | − 0.41 (− 0.66, − 0.09) | 0.006 | 0.04 (− 0.12, 0.16) | 0.614 | 10.11 |
cg10528482 | SLC9A3 | − 0.25 (− 0.41, − 0.09) | 0.002 | − 0.18 (− 0.35, − 0.01) | 0.044 | − 0.07 (− 0.16, 0.01) | 0.076 | 28.5 |