Fig. 6

Sites commonly affected by in vivo and in vitro ARTs may represent robust hypofertility-related DNA methylation changes. A Venn diagram showing sites commonly affected in both ART subgroups. Methylation differences of in vivo and in vitro groups relative to the control group for DMCs common between both ART subgroups are shown, with DMCs demonstrating methylation changes in the same or opposite direction for both groups indicated in grey and purple, respectively. B Significantly enriched biological processes obtained after STRING analysis was performed using genes only annotated to genic DMCs for either the in vivo or in vitro group. Arrows indicate biological processes related to neurodevelopment. FDR; false discovery rate