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Table 2 Top 20 CpGs differentially methylated between VLBW versus controls and associations with birthweight or gestation, adjusting for study group, sex and ethnicity (full list of 16,408 CpGs FDR-adj p < 0.05 in Additional file 11: Table S2)

From: DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight

CpG ID and nearest gene

Chromosome: location

p value

FDR-adj p value*

Fold change

R statistic

Direction in VLBW

Birthweight p value and direction (full Cohort)

Gestation p value and direction (VLBW cases)

cg02001279

ARID3A

19:940,967

1.01E−37

8.28E−32

1.153

0.862

Hypermethylated

0.003

+

 < 0.001

+

cg07835443

SPATA33/C16orf55

16:89,734,986

3.17E−35

1.30E−29

1.217

0.847

Hypermethylated

 < 0.001

+

 < 0.001

+

cg10461390

LRBA

4:151,324,223

9.63E−30

2.64E−24

1.154

0.808

Hypermethylated

 < 0.001

+

 < 0.001

+

cg04347477

NCOR2

12:125,002,007

1.76E−29

3.62E−24

1.177

0.805

Hypermethylated

0.008

+

 < 0.001

+

cg25975961

KCNH2

7:150,600,818

1.97E−28

3.24E−23

1.144

0.797

Hypermethylated

ns

 

ns

 

cg17307655

WHRN/DFNB31

9:117,214,672

2.42E−28

3.31E−23

1.143

0.796

Hypermethylated

 < 0.001

+

 < 0.001

+

cg16725984

SPATA33/C16orf55

16:89,735,184

5.52E−28

6.49E−23

1.127

0.793

Hypermethylated

0.015

+

 < 0.001

+

cg06870470

DOCK6

19:11,315,767

1.31E−27

1.35E−22

1.167

0.789

Hypermethylated

0.004

+

 < 0.001

+

cg09476997

SLC9A3R2

16:2,087,932

8.45E−27

7.72E−22

0.815

− 0.782

Hypomethylated

0.007

–

0.002

–

cg12713583

ARID3A

19:940,724

9.54E−27

7.85E−22

1.134

0.781

Hypermethylated

0.012

+

 < 0.001

+

cg19274030

ST3GAL6

3:98,489,745

2.12E−26

1.58E−21

1.116

0.778

Hypermethylated

0.002

+

 < 0.001

+

cg00406098

LINC00598

13:40,716,180

4.19E−26

2.65E−21

1.123

0.775

Hypermethylated

0.001

+

0.006

+

cg06063190

RNA5SP318

10:55,163,525

4.41E−26

2.65E−21

1.119

0.775

Hypermethylated

0.025

+

0.007

+

cg11932158

PLCH1

3:155,422,129

4.50E−26

2.65E−21

1.099

0.775

Hypermethylated

ns

 

0.033

 

cg19333758

RAPGEF3

12: 48,135,549

7.05E−26

3.87E−21

1.166

0.773

Hypermethylated

0.003

+

 < 0.001

+

cg19744173

FBLN7

2:112,913,178

7.73E−26

3.98E−21

1.102

0.773

Hypermethylated

 < 0.001

+

 < 0.001

+

cg25715278

OAT

10:126,040,305

3.21E−25

1.55E−20

1.076

0.767

Hypermethylated

0.013

+

 < 0.001

+

cg26708048

DLG4

17: 7,087,655

1.08E−24

4.94E−20

1.121

0.761

Hypermethylated

0.042

+

0.002

+

cg18623216

PLCH1

3:155,421,970

1.24E−24

5.12E−20

1.102

0.761

Hypermethylated

ns

 

ns

 

cg12405088

PACSIN2

22:43,257,120

1.24E−24

5.12E−20

1.101

0.761

Hypermethylated

0.049

+

 < 0.001

+

  1. * Benjamini–Hochberg FDR p value is corrected for 822,741 CpG sites. R statistic is correlation coefficient for continuous variables
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Clinical Epigenetics

ISSN: 1868-7083

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