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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Inactivation of ZSCAN18 by promoter hypermethylation drives the proliferation via attenuating TP53INP2-mediated autophagy in gastric cancer cells

Fig. 6

ZSCAN18-induced suppression of GC cell proliferation is mediated by TP53INP2. Three groups of cells were established in both AGS and NCI-N87 cells: ZSCAN18 overexpression and TP53INP2 knockdown (ZSCAN18 + shTP53INP2), ZSCAN18 overexpression and empty vector knockdown (ZSCAN18 + shVector), empty vector and empty vector knockdown (Vector + shVector). A Alteration of cell viability was detected among three groups in both AGS and NCI-N87 cells. B Alteration of colony formation was detected among three groups in both AGS and NCI-N87 cells. C The lethal effect in vivo was detected among three groups in NCI-N87 cells. D, E The autophagic flux was detected among three groups in both AGS and NCI-N87 cells. Each experiment was performed in triplicate and repeated at least three times. Data were represented as mean ± SD. ****p < 0.0001

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Clinical Epigenetics

ISSN: 1868-7083

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