Table 4 Effect estimates and p values of the CpGs identified in the meta-analysis by Imboden et al. that were replicated in the SHS
CpG | Chr | Gene | Lung function endpoint in meta-analysis | Coefficient (SE) in meta-analysis | p value in meta-analysis | Lung function endpoint in the SHS | Coefficient of the elastic-net model in the SHS |
|---|---|---|---|---|---|---|---|
cg05575921 | 5 | AHRR | FEV1; FVC; FEV1/FVC | 0.78 (0.057); 0.37 (0.064); 0.12 (0.008) | 1.48E−43; 8.79E−09; 7.22E−50 | FEV1/FVC | 1.10 |
cg03636183 | 19 | F2RL3 | FEV1; FVC; FEV1/FVC | 1.27 (0.098); 0.62 (0.11); 0.20 (0.015) | 4.08E−39; 2.04E−08; 4.5E−43 | FEV1/FVC | 1.13 |
cg21566642 | 2 | ALPPL2 | FEV1; FEV1/FVC | 0.94 (0.074); 0.15 (0.011) | 7.43E−37; 5.02E−43 | FEV1/FVC | 0.21 |
cg03329539 | 2 | ALPPL2 | FEV1; FEV1/FVC | 1.61 (0.15); 0.26 (0.023) | 1.46E−26; 5.58E−30 | FEV1/FVC | 0.76 |
cg24859433 | 6 | IER3 | FEV1/FVC | 0.30 (0.034) | 2.05E−19 | FEV1 | 0.019 |
cg19859270 | 3 | GPR15 | FEV1; FEV1/FVC | 2.74 (0.36); 0.47 (0.06) | 1.34E−14; 2.8E−18 | FEV1/FVC | 2.46 |
cg18181703 | 17 | SOCS3 | FEV1 | 1.19 (0.16) | 3.74E−14 | FEV1; FVC | 0.093; 0.034 |
cg01127300 | 22 | TMEM184B | FEV1 | 0.85 (0.12) | 1.19E−12 | FEV1/FVC | 0.057 |
cg06826457 | 12 | CDKN1B | FEV1 | 1.12 (0.18) | 5.35E−10 | Airflow limitation; FEV1/FVC | − 0.028; 0.13 |