Table 2 Top five differentially methylated positions for continuous lung function measures (FEV1, FVC, and FEV1/FVC)
CpG | Chr | Gene | Function | Mean difference (95% CI) | p value |
|---|---|---|---|---|---|
FEV1 | |||||
cg25325512 | 6 | PIM1 | Serine/Threonine-Protein Kinase Pim-1. Cell proliferation and survival | 0.22 (0.15, 0.29) | 2.91E−09 |
cg26058502 | 1 | CERS2 | Regulation of cell growth and lipid metabolism | 0.18 (0.11, 0.25) | 2.79E−07 |
cg01641754 | 5 | LOC100289230 | Uncharacterized | 0.18 (0.11, 0.24) | 3.46E−07 |
cg15167811 | 9 | PTBP3 | Regulator of cell differentiation | 0.16 (0.1, 0.23) | 4.85E−07 |
cg07941411 | 3 | CD80 | T-cell proliferation and cytokine production |  − 0.15 (− 0.21, − 0.09) | 2.00E−06 |
FVC | |||||
cg02203833 | 7 | CDK5 | Serine/threonine kinase. Synaptic plasticity and neuronal migration | 0.21 (0.12, 0.30) | 4.00E−06 |
cg19265480 | 1 | NBPF8 | Associated with developmental and neurogenetic diseases |  − 0.19 (− 0.27, − 0.11) | 3.00E−06 |
cg18140268 | 1 | NBPF8 | Associated with developmental and neurogenetic diseases |  − 0.18 (− 0.26, − 0.11) | 5.00E−06 |
cg07343418 | 12 | GRIN2B | Brain development, synaptic plasticity |  − 0.19 (− 0.26, − 0.11) | 2.00E−06 |
cg03725414 | 16 | CRISPLD2 | Promotes matrix assembly | 0.18 (0.10, 0.26) | 1.30E−05 |
FEV1/FVC | |||||
cg25001882 | 14 | NRXN3 | Cell adhesion in the nervous system, synaptic plasticity | 33.0 (21.3, 44.6) | 3.32E−08 |
cg16771344 | 9 | NTRK2 | Tyrosine receptor kinase. Phosphorylates itself and members of the MAPK signaling pathway | 29.9 (18.5, 41.2) | 2.99E−07 |
cg12420787 | 2 | CACNB4 | Calcium channel. Plasticity on the brain | 21.7 (13.4, 30.1) | 3.84E−07 |
cg03636183 | 19 | F2RL3 | Blood coagulation, inflammation and response to pain. Associated with smoking and lung cancer | 18.1 (11.0, 25.2) | 5.80E−07 |
cg27127773 | 16 | SLX4 | Repair of specific types of DNA lesions |  − 42.6 (− 59.2, − 25.9) | 6.17E−07 |