Table 1 Writers, erasers, and potential readers for broad H3K4me3 domains
From: The dynamic broad epigenetic (H3K4me3, H3K27ac) domain as a mark of essential genes
Writers | Erasers | Readers |
|---|---|---|
KMT2F (uH2B requirement) | KDM5A-D | Transcription regulation [TAF3, 4, 9 (TFIID complex), transcription factor (BPTF)-associated protein of 18Â kDa (BAP18), Spindlin1, ING proteins] |
KMT2G (no uH2B requirement) | Â | Chromatin modification [PHF23 which recruits SIN3-HDAC, KDM5B; ING proteins which are associated with KATs and HDAC complexes, KATs (KAT3B, KAT2B, KAT7, KAT2A in SAGA complex), SGF29 (SAGA), KMTs (WDR5)] |
| Â | Â | Chromatin remodeling (CHD1, NURF) |
| Â | Â | Elongation (PAF, FACT) |
| Â | Â | RNA splicing (U2 snRNP, U2AF65) |
| Â | Â | Bromodomain proteins (BPTF) |
| Â | Â | Protein members of Integrator and Mediator complexes |
| Â | Â | Transcriptional processes (ADAR1) |