Table 2 Fold enrichment, biological processes and molecular functions of a few TH2B associated genes
From: Epigenetic landscape of testis specific histone H2B variant and its influence on sperm function
Gene name | Protein name | Fold enrichment | p value | GO biological process | GO molecular function |
|---|---|---|---|---|---|
CREM | cAMP-responsive element modulator | 6.74 | 6 × 10–4 | DNA-binding transcription factor activity, Regulation of transcription, Signal transduction,Multicellular organism development, Spermatogenesis | DNA binding, RNA polymerase II transcription factor activity, Transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
PRKAG2 | 5′-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) | 5.9 | 7 × 10–4 | ATP biosynthetic process, Fatty acid biosynthetic process, Intracellular signal transduction, Positive regulation of protein kinase activity, Regulation of glycolytic process, regulation of signal transduction | AMP-activated protein kinase activity, AMP binding, ATP binding, cAMP-dependent protein kinase regulator activity, Phosphorylase kinase regulator activity [GO:0008607]; protein kinase activator activity |
CDYL | Chromodomain Y-like protein (CDY-like) (Crotonyl-CoA hydratase) | 29.5 | 1 × 10–5 | Negative regulation of peptidyl-lysine crotonylation, Random inactivation of X chromosome, Regulation of transcription, Spermatid development, spermatogenesis | Chromatin binding, Crotonyl-CoA hydratase activity, Methylated histone binding, Protein binding, Transcription corepressor activity |
CATSPERB | Cation channel sperm-associated protein subunit beta (CatSper-beta) | 5.06 | 7 × 10–4 | Multicellular organism development, Response to progesterone, Sperm capacitation, Sperm-egg recognition | CatSpercomplex,Integral component of sperm membrane |
TSGA10 | Testis-specific gene 10 protein (Testis development protein NYD-SP7) | 5.9 | 3 × 10–4 | Cell projection assembly, Spermatogenesis | Protein binding |
TSSK1B | Testis-specific serine/threonine-protein kinase 1 | 5.9 | 3 × 10–4 | Intracellular signal transduction, Multicellular organism development, Protein phosphorylation, Spermatid development | ATP binding, Magnesium ion binding, Protein serine/threonine kinase activity |