Genome-wide DNA methylation profiling is able to identify prefibrotic PMF cases at risk for progression to myelofibrosis

Table 1 Genomic localization and functional annotation of the 6 CpG sites shown in Fig. 2a

Chr	Name	Localization	Associated gene		Coefficient for LDM
16	cg03983220	OpenSea	None		− 7.431161
10	cg11628316	Island	NM_001008541	Max-interacting protein 1	− 44.910325
2	cg08880875	N_Shore	NM_138804	Meiosis 1 Associated Protein	− 11.469252
13	cg21459486	OpenSea	none		− 9.140643
16	cg05972185	OpenSea	NM_001164766	Zinc finger homeobox 3	6.017707
19	cg18376352	Island	NM_004750	Cytokine Receptor-Like Factor 1	12.946803

For the definition and nomenclature of CpG islands, shores, open sea, and shelves, see [49, 50]
LDM Linear discriminant model

ISSN: 1868-7083