Genetic and environmental determinants of O6-methylguanine DNA-methyltransferase (MGMT) gene methylation: a 10-year longitudinal study of Danish twins

Wang, Lijie; Mohammadnejad, Afsaneh; Li, Weilong; Lund, Jesper; Li, Shuxia; Clemmensen, Signe; Timofeeva, Maria; Soerensen, Mette; Mengel-From, Jonas; Christensen, Kaare; Hjelmborg, Jacob; Tan, Qihua

doi:10.1186/s13148-021-01009-5

Table 3 Heritability estimation at top 47 CpG sites of MGMT with common environmental component at two time points

From: Genetic and environmental determinants of O⁶-methylguanine DNA-methyltransferase (MGMT) gene methylation: a 10-year longitudinal study of Danish twins

CpG site	Year 1997			Year 2007
CpG site	a²	c²	e²	a²	c²	e²
cg03751055^c	0.0000 (0.0000–0.0000)	0.9792 (0.9629–0.9955)	0.0208 (0.0045–0.0371)	0.0000 (0.0000–0.0000)	0.9841 (0.9716–0.9966)	0.0159 (0.0034–0.0284)
cg25063211^c	0.0000 (0.0000–0.0000)	0.8925 (0.8297–0.9554)	0.1075 (0.0446–0.1703)	0.0000 (0.0000–0.0000)	0.6785 (0.4072–0.9498)	0.3215 (0.0502–0.5928)
cg07933035^c	0.0000 (0.0000–0.0000)	0.8541 (0.7232–0.9851)	0.1459 (0.0149–0.2768)	0.0000 (0.0000–0.0000)	0.8015 (0.6090–0.9941)	0.1985 (0.0059–0.3910)
cg12434587^c	0.0000 (0.0000–0.0000)	0.8136 (0.6495–0.9777)	0.1864 (0.0223–0.3505)	0.0000 (0.0000–0.0000)	0.8186 (0.6494–0.9878)	0.1814 (0.0122–0.3506)
cg26102564^c	0.0000 (0.0000–0.0000)	0.7358 (0.5942–0.8774)	0.2642 (0.1226–0.4058)	0.0000 (0.0000–0.0000)	0.8214 (0.7199–0.9229)	0.1786 (0.0771–0.2801)
cg18811130^c	0.0000 (0.0000–0.0000)	0.6892 (0.5240–0.8544)	0.3108 (0.1456–0.4760)	0.0000 (0.0000–0.0000)	0.7466 (0.6094–0.8838)	0.2534 (0.1162–0.3906)
cg12981137^c	0.0000 (0.0000–0.0000)	0.6138 (0.2981–0.9295)	0.3862 (0.0705–0.7019)	0.0000 (0.0000–0.0000)	0.7168 (0.4396–0.9940)	0.2832 (0.0060–0.5604)
cg02941816^c	0.0000 (0.0000–0.0000)	0.5689 (0.1537–0.9841)	0.4311 (0.0159–0.8463)	0.0000 (0.0000–0.0000)	0.7174 (0.4562–0.9786)	0.2826 (0.0214–0.5438)
cg13474692^c	0.0000 (0.0000–0.0000)	0.5595 (0.1543–0.9646)	0.4405 (0.0354–0.8457)	0.0000 (0.0000–0.0000)	0.6074 (0.1231–1.0917)	0.3926 (− 0.0917–0.8769)
cg02750154^c	0.0000 (0.0000–0.0000)	0.5114 (0.2660–0.7567)	0.4886 (0.2433–0.7340)	0.0000 (0.0000–0.0000)	0.7505 (0.6022–0.8988)	0.2495 (0.1012–0.3978)
cg18581292^c	0.0000 (0.0000–0.0000)	0.3584 (0.0683–0.6484)	0.6416 (0.3516–0.9317)	0.0000 (0.0000–0.0000)	0.4864 (0.2308–0.7420)	0.5136 (0.2580–0.7692)
cg06566239^a	0.0000 (0.0000–0.0000)	0.6584 (0.4027–0.9141)	0.3416 (0.0859–0.5973)	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)
cg00618725^a	0.0000 (0.0000–0.0000)	0.6405 (0.2705–1.0106)	0.3595 (− 0.0106–0.7295)	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)
cg14312783^a	0.0000 (0.0000–0.0000)	0.5993 (0.2752–0.9234)	0.4007 (0.0766–0.7248)	0.0000 (0.0000–0.0000)	0.3585 (− 1.1327–1.8496)	0.6415 (− 0.8496–2.1327)
cg24420981^a	0.0000 (0.0000–0.0000)	0.5814 (0.0205–1.1423)	0.4186 (− 0.1423–0.9795)	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)
cg11223735^a	0.0000 (0.0000–0.0000)	0.5367 (0.1905–0.8829)	0.4633 (0.1171–0.8095)	0.4334 (NaN–NaN)	0.0000 (0.0000–0.0000)	0.5666 (NaN–NaN)
cg16648911^a	0.0000 (0.0000–0.0000)	0.5177 (0.2552–0.7802)	0.4823 (0.2198–0.7448)	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)
cg16698623^a	0.0000 (0.0000–0.0000)	0.5145 (0.2241–0.8050)	0.4855 (0.1950–0.7759)	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)
cg17307615^a	0.0000 (0.0000–0.0000)	0.5057 (0.1429–0.8685)	0.4943 (0.1315–0.8571)	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)
cg19806483^a	0.0000 (0.0000–0.0000)	0.4869 (0.0110–0.9628)	0.5131 (0.0372–0.9890)	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)
cg18485261^a	0.0000 (0.0000–0.0000)	0.4861 (0.0492–0.9230)	0.5139 (0.0770–0.9508)	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)
cg11948988^a	0.0000 (0.0000–0.0000)	0.4843 (0.0623–0.9064)	0.5157 (0.0936–0.9377)	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)
cg25946389^a	0.0000 (0.0000–0.0000)	0.4715 (0.0162–0.9269)	0.5285 (0.0731–0.9838)	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)
cg17380475^a	0.0000 (0.0000–0.0000)	0.4228 (0.1566–0.6890)	0.5772 (0.3110–0.8434)	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)
cg19680672^a	0.0000 (0.0000–0.0000)	0.4005 (0.1212–0.6798)	0.5995 (0.3202–0.8788)	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)
cg26528551^a	0.0000 (0.0000–0.0000)	0.3832 (0.1061–0.6604)	0.6168 (0.3396–0.8939)	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)
cg15312358^a	0.0000 (0.0000–0.0000)	0.3783 (0.0587–0.6980)	0.6217 (0.3020–0.9413)	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)
cg19706602^a	0.0000 (0.0000–0.0000)	0.3529 (0.0763–0.6296)	0.6471 (0.3704–0.9237)	0.0000 (0.0000–0.0000)	0.2628 (− 0.0376–0.5632)	0.7372 (0.4368–1.0376)
cg26976729^a	0.0000 (0.0000–0.0000)	0.3230 (0.0260–0.6199)	0.6770 (0.3801–0.9740)	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)
cg13171643^a	0.0000 (0.0000–0.0000)	0.3145 (0.0155–0.6135)	0.6855 (0.3865–0.9845)	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)
cg25557018^a	0.0000 (0.0000–0.0000)	0.3061 (0.0044–0.6077)	0.6939 (0.3923–0.9956)	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)
cg27000233^b	0.0000 (0.0000–0.0000)	0.3263 (NaN–NaN)	0.6737 (NaN–NaN)	0.0000 (0.0000–0.0000)	0.3029 (0.1708–0.4349)	0.6971 (0.5651–0.8292)
cg14194875^b	0.0000 (0.0000–0.0000)	0.2670 (− 0.0342–0.5682)	0.7330 (0.4318–1.0342)	0.0000 (0.0000–0.0000)	0.6596 (0.3137–1.0056)	0.3404 (− 0.0056–0.6863)
cg27483317^b	0.7057 (0.4854–0.9261)	0.0000 (0.0000–0.0000)	0.2943 (0.0739–0.5146)	0.0000 (0.0000–0.0000)	0.5641 (0.2106–0.9176)	0.4359 (0.0824–0.7894)
cg07367735^b	0.3773 (− 0.0659–0.8206)	0.0000 (0.0000–0.0000)	0.6227 (0.1794–1.0659)	0.0000 (0.0000–0.0000)	0.5802 (0.0485–1.1119)	0.4198 (− 0.1119–0.9515)
cg05596517^b	0.3609 (− 0.0911–0.8130)	0.0000 (0.0000–0.0000)	0.6391 (0.1870–1.0911)	0.0000 (0.0000–0.0000)	0.5740 (0.1702–0.9779)	0.4260 (0.0221–0.8298)
cg00639517^b	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)	0.0000 (0.0000–0.0000)	0.4576 (0.1108–0.8045)	0.5424 (0.1955–0.8892)
cg04540870^b	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)	0.0000 (0.0000–0.0000)	0.2222 (0.1253–0.3190)	0.7778 (0.6810–0.8747)
cg05068430^b	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)	0.0000 (0.0000–0.0000)	0.6789 (0.3242–1.0335)	0.3211 (− 0.0335–0.6758)
cg07448909^b	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)	0.0000 (0.0000–0.0000)	0.3512 (0.0368–0.6656)	0.6488 (0.3344–0.9632)
cg09154334^b	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)	0.0000 (0.0000–0.0000)	0.3255 (0.0383–0.6127)	0.6745 (0.3873–0.9617)
cg11019008^b	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)	0.0000 (0.0000–0.0000)	0.4915 (0.0430–0.9400)	0.5085 (0.0600–0.9570)
cg11216456^b	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)	0.0000 (0.0000–0.0000)	0.3477 (0.0523–0.6431)	0.6523 (0.3569–0.9477)
cg11235543^b	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)	0.0000 (0.0000–0.0000)	0.3398 (0.2386–0.4410)	0.6602 (0.5590–0.7614)
cg23235067^b	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)	0.0000 (0.0000–0.0000)	0.4256 (0.1038–0.7473)	0.5744 (0.2527–0.8962)
cg24747557^b	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)	0.0000 (0.0000–0.0000)	0.3091 (0.0123–0.6058)	0.6909 (0.3942–0.9877)
cg27429313^b	0.0000 (0.0000–0.0000)	0.0000 (0.0000–0.0000)	1.0000 (1.0000–1.0000)	0.0000 (0.0000–0.0000)	0.3577 (0.0478–0.6677)	0.6423 (0.3323–0.9522)

^a,bRepresent significant CpG sites with significant common environmental component with 0 not included in the 2.5–97.5% confidence intervals in 1997 and 2007, respectively
^cRepresents overlapped significant CpG sites between 1997 and 2007 with common environmental component

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ISSN: 1868-7083

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