Table 2 Clinicopathological parameters of the 136 primary melanomas with known sentinel lymph node status
H3K27me3 + | H3K27me3− | p value | ||
|---|---|---|---|---|
n (%) | n (%) | n (%) | ||
Number | 136 | 42 (30,9) | 94 (69,1) | |
Age (years): median (range) | 59 (20-87) | 62 ( 22-84) | 58 (20-87) | |
Gender | ||||
Female | 60 (44.1) | 20 (33.3) | 40 (66.7) | p = .583 |
Male | 76 (55.9) | 23 (30.3) | 53 (69.7) | |
Thickness: median | ||||
< 1.0 mm | 24 (17.6) | 5 (20.8) | 19 (79.2) | |
1.01–2.0 mm | 61 (44.9) | 14 (23.0) | 47 (77.0) | p = .033* |
2.01–4.0 mm | 32 (23.5) | 16 (50.0) | 16 (50.0) | |
> 4 mm | 19 (14.0) | 7 (36.8) | 12 (63.2) | |
Histologic subtype | ||||
Superficial spreading | 66 (48.5) | 21 (31.8) | 45 (68.2) | |
Nodular | 53 (39.0) | 17 (32.1) | 36 (67.9) | p = .730 |
Lentigious malignant | 2 (1.5) | 0 (0) | 2 (100) | |
Acral melanoma | 13 (9.6) | 4 (30.8) | 9 (69.2) | |
Other | 2 (1.5) | 0 (0) | 2 (100) | |
Ulceration | ||||
Positive | 56 (41.2) | 20 (35.7) | 36 (64.3) | p = .308 |
Negative | 80 (58.8) | 22 (27.5) | 58 (72.5) | |
Sentinel lymph node status | ||||
Positive | 32 (23.5) | 15 (46.9) | 17 (53.1) | p = .025* |
Negative | 104 (76.5) | 27 (26.0) | 77 (74.0) | |
Pigment | ||||
Positive | 80 (58.8) | 29 (36.2) | 51 (63.8) | p = .105 |
Negative | 56 (41.2) | 13 (23.2) | 43 (76.8) | |
Tumor-infiltrating lymphocytes | ||||
Absent | 58 (42.6) | 17 (29.3) | 41 (70.7) | p = .872 |
Non-brisk | 18 (13.2) | 5 (27.8) | 13 (72.2) | |
Brisk | 60 (44.1) | 20 (33.3) | 40 (66.7) | |