Fig. 2From: Evaluation of a panel of tumor-specific differentially-methylated DNA regions in IRF4, IKZF1 and BCAT1 for blood-based detection of colorectal cancerPositivity by progression of cellular atypia (dysplasia in adenomas) and degree of invasion (T stage in cancer), in cases without disseminated disease. LGD low grade dysplasia, HGD high grade dysplasia. Y axis: average detection rates, % (sensitivity). Closed black circles—at least one PCR replicate positive for methylation in any of the three genes; blue, red and black symbols—detection rates of the individual methylation markers, IRF4, IKZF1 and BCAT1, respectively. Additional file 1: Table S1 provides details for count of positives, % detected and 95% CI. *Only 53 of the 57 Stage II cases had full TNM informationBack to article page