| Discovery cohort | Replication cohort | |||||
---|---|---|---|---|---|---|---|
Categorical phenotypes | |||||||
Measure | Variable | n event | OR | P | n event | OR | P |
DNAm GrimAge | COPD | 48 | 2.00 | 1.0 × 10−4 | 32 | 3.29 | 3.4 × 10−4 |
Continuous phenotypes | |||||||
Measure | Variable | n | β | P | n | β | P |
DunedinPoAm | Pack Years | 2419 | 0.45 | 1.2 × 10−112 | 1340 | 0.33 | 7.6 × 10−36 |
DNAm TL | Pack Years | 2419 | -0.14 | 1.1 × 10−11 | 1340 | -0.18 | 2.7 × 10−11 |
DNAm PhenoAge | Pack Years | 2419 | 0.11 | 3.0 × 10−08 | 1340 | 0.16 | 9.5 × 10−10 |
DNAm GrimAge | SIMD | 2419 | -0.13 | 5.9 × 10−08 | 1340 | -0.19 | 4.6 × 10−09 |
DNAm GrimAge | Average Heart Rate | 2416 | 0.19 | 1.4 × 10−12 | 1339 | 0.20 | 1.6 × 10−08 |
DunedinPoAm | SIMD | 2419 | -0.13 | 1.8 × 10−09 | 1340 | -0.16 | 2.2 × 10−08 |
Hannum Age | Creatinine | 2406 | 0.21 | 1.4 × 10−26 | 1334 | 0.13 | 4.2 × 10−07 |
DNAm GrimAge | FEF | 2055 | -0.12 | 1.2 × 10−06 | 1149 | -0.15 | 1.4 × 10−06 |
DNAm PhenoAge | Body Mass Index | 2419 | 0.12 | 2.5 × 10−10 | 1340 | 0.12 | 7.4 × 10−06 |
DNAm PhenoAge | Average Heart Rate | 2416 | 0.11 | 2.1 × 10−07 | 1339 | 0.12 | 7.7 × 10−06 |
DNAm GrimAge | FEV | 2074 | -0.08 | 2.0 × 10−05 | 1151 | -0.10 | 1.4 × 10−04 |
DNAm GrimAge | Creatinine | 2406 | 0.19 | 3.0 × 10−15 | 1334 | 0.13 | 2.0 × 10−04 |
DunedinPoAm | Average Heart Rate | 2416 | 0.19 | 1.6 × 10−15 | 1339 | 0.11 | 2.2 × 10−04 |
Mortality analysis | |||||||
Measure | Variable | n event | HR | P | n events | HR | P |
DNAm GrimAge | All-cause mortality | 89 | 1.62 | 1.4 × 10−4 | 30 | 2.10 | 5.6 × 10−4 |