Fig. 3

An integrative circos plot of epigenomic and transcriptomic alterations in OSCC-GB. The outermost track displays the human genome (hg19) ideogram by chromosome number. The second track depicts frequency distribution of epigenome-wide significantly differentially methylated CpG sites. The third track provides the distribution of coding genes, with differential methylation in their promoter regions. Hypermethylation and hypomethylation are represented by red and green colors, respectively. The fourth track presents transcriptomic profiles in autosomes—upregulated and downregulated genes are shown in purple and blue, respectively. The inner most track represents the 209 genes that showed significant inverse correlation between promoter methylation and expression. Of these 209, 36 (17.2%) genes are on chromosome 19. Heights of blue bars are proportional to the correlation coefficients. The color-coded links represent genes from the significantly dysregulated pathways (n = 5). Gene names from the pathways are shown outside the ideogram. (Cyan, arachidonic acid metabolism; Yellow, longevity regulating pathway; Orange, PPAR signaling pathway; Green, B cell receptor signaling pathway; Purple, acute myeloid leukemia)