Table 1 Gene set enrichment analysis of significantly changed gene expression in UNC0642-treated PEO1-OR HGSOC cells
Gene set name | # Genes in set (K) | Description | # Genes in overlap (k) | k/K % | p value | FDR q value |
|---|---|---|---|---|---|---|
MTORC1 Signaling | 200 | Genes upregulated through activation of mTORC1 complex | 43 | 22% | 9.22E-20 | 4.61E-18 |
MYC Targets | 200 | A subgroup of genes regulated by MYC | 41 | 21% | 4.06E-18 | 1.02E-16 |
Unfolded Protein Response | 113 | Genes upregulated during unfolded protein response in the endoplasmic reticulum | 30 | 27% | 6.52E-17 | 1.09E-15 |
Hypoxia | 200 | Genes upregulated in response to hypoxia | 39 | 20% | 1.59E-16 | 1.98E-15 |
PI3K/AKT/ mTOR Signaling | 105 | Genes upregulated by activation of the PI3K/AKT/mTOR pathway | 28 | 27% | 6.17E-16 | 6.17E-15 |
Cholesterol Homeostasis | 74 | Genes involved in cholesterol homeostasis | 23 | 31% | 6.18E-15 | 5.15E-14 |
Oxidative Phosphor-ylation | 200 | Genes involved in oxidative phosphorylation | 36 | 18% | 3.04E-14 | 1.90E-13 |
Xenobiotic Metabolism | 200 | Genes involved in processing of drugs and other xenobiotics | 36 | 18% | 3.04E-14 | 1.90E-13 |
DNA Repair | 150 | Genes involved in DNA repair | 30 | 20% | 2.37E-13 | 1.32E-12 |
IL2/STAT5 Signaling | 200 | Genes upregulated by STAT5 in response to IL2 stimulation | 34 | 17% | 8.56E-13 | 3.89E-12 |