Table 2 Correlations of TIM-3 and LGALS9 methylation and TIM-3 and galectin 9 mRNA expression with interferon-γ signature

TIM-3 mRNA

0.795

< 0.001

0.694

< 0.001

0.297

< 0.001

0.481

< 0.001

0.525

< 0.001

TIM-3 cg19110684 (1)

− 0.400

< 0.001

− 0.297

< 0.001

− 0.205

< 0.001

− 0.123

0.008

− 0.323

< 0.001

TIM-3 cg19646897 (2)

− 0.505

< 0.001

− 0.422

< 0.001

− 0.221

< 0.001

− 0.230

< 0.001

− 0.335

< 0.001

TIM-3 cg15371617 (3)

− 0.254

< 0.001

− 0.224

< 0.001

− 0.191

< 0.001

− 0.052

0.26

− 0.206

< 0.001

TIM-3 cg17484237 (4)

− 0.171

< 0.001

− 0.161

< 0.001

− 0.207

< 0.001

0.041

0.38

− 0.171

< 0.001

TIM-3 cg19063654 (5)

0.140

0.002

0.098

0.034

− 0.036

0.44

0.236

< 0.001

0.062

0.18

TIM-3 cg18374914 (5)

0.549

< 0.001

0.417

< 0.001

0.201

< 0.001

0.340

< 0.001

0.397

< 0.001

Galectin 9 mRNA

0.639

< 0.001

0.556

< 0.001

0.322

< 0.001

0.346

< 0.001

0.613

< 0.001

LGALS9 cg19654781 (6)

− 0.188

< 0.001

− 0.143

0.002

− 0.052

0.26

0.001

0.99

− 0.185

< 0.001

LGALS9 cg10699049 (7)

− 0.049

0.29

− 0.057

0.22

− 0.029

0.53

− 0.013

0.79

− 0.057

0.22

LGALS9 cg27625456 (8)

− 0.241

< 0.001

− 0.217

< 0.001

− 0.198

< 0.001

− 0.067

0.15

− 0.269

< 0.001

LGALS9 cg21157094 (9)

− 0.282

< 0.001

− 0.252

< 0.001

− 0.201

< 0.001

− 0.054

0.25

− 0.270

< 0.001

LGALS9 cg23290146 (10)

− 0.355

< 0.001

− 0.307

< 0.001

− 0.155

0.001

− 0.158

0.001

− 0.278

< 0.001

LGALS9 cg05105919 (11)

− 0.536

< 0.001

− 0.426

< 0.001

− 0.231

< 0.001

− 0.299

< 0.001

− 0.397

< 0.001

LGALS9 cg03909504 (12)

0.280

< 0.001

0.258

< 0.001

0.180

< 0.001

0.254

< 0.001

0.223

< 0.001

LGALS9 cg06852032 (13)

0.054

0.25

0.084

0.069

0.105

0.022

0.161

< 0.001

0.060

0.19