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Table 6 Correlations between serum B vitamin biomarkers and oxidative biomarkers

From: Dietary intakes and biomarker patterns of folate, vitamin B6, and vitamin B12 can be associated with cognitive impairment by hypermethylation of redox-related genes NUDT15 and TXNRD1

 

Oxidative biomarkers

ROS (IU/ml)

MDA (mmol/L)

8-OHdG (ng/L)

8-iso-PGF2α (ng/L)

r

FDR adjusted P value

r

FDR adjusted P value

r

FDR adjusted P value

r

FDR adjusted P value

Serum B vitamin biomarkers

Folate (μg/L)

− 0.507

< 0.001*

− 0.432

< 0.001*

− 0.653

< 0.001*

− 0.568

< 0.001*

Vitamin B6 (ng/L)

0.069

0.742

0.155

0.293

− 0.008

0.991

0.194

0.223

Vitamin B12 (ng/L)

0.114

0.588

0.109

0.588

0.220

0.097

0.177

0.194

Hcy (μmol/L)

0.564

< 0.001*

0.400

< 0.001*

0.666

< 0.001*

0.547

< 0.001*

  1. Hcy homocysteine, ROS reactive oxygen species, MDA malondialdehyde, 8-OHdG 8-hydroxy-desoxyguanosine, 8-iso-PGF2α 8-iso-prostaglandin F2α, FDR false discovery rate
  2. ∗P < 0.05
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Clinical Epigenetics

ISSN: 1868-7083

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