Fig. 3From: “Too much guts and not enough brains”: (epi)genetic mechanisms and future therapies of Hirschsprung disease — a reviewa, b DNA methylation. In the promoter area of genes, hypomethylation of the CpG island increases gene expression, while hypermethylation of the CpG island reduces gene expression. Hence, DNA hypomethylation activates genes while hypermethylation silences themBack to article page