Table 4 Assessment of OPCML, HOXA9, and HOXD9 as differential biomarkers between CCA and other biliary diseases
Gene (cut off) | % Sensitivity | % Specificity | % Accuracy | %PPV | %NPV | AUC (95%CI) | P value |
|---|---|---|---|---|---|---|---|
OPCML (3.24%) | 80.00 (32/40) | 90.00 (36/40) | 85.00 (66/80) | 88.88 (32/36) | 81.81 (36/44) | 0.850 (0.759–0.941) | < 0.0001 |
HOXD9 (1.56%) | 67.50 (27/40) | 90.00 (36/40) | 78.75 (63/80) | 87.09 (27/31) | 73.46 (36/49) | 0.788 (0.686–0.892) | < 0.0001 |
HOXA9 (1.56%) | 47.50 (19/40) | 62.50 (25/40) | 55.00 (44/80) | 55.58 (19/34) | 54.34 (25/46) | 0.550 (0.423–0.676) | 0.441 |
OPCML + HOXD9 | 62.50 (25/40) | 100.00 (40/40) | 81.25 (65/80) | 100.00 (25/25) | 72.72 (40/55) | 0.812 (0.713–0.911) | < 0.0001 |
OPCML + HOXA9 | 30.00 (12/40) | 97.50 (39/40) | 63.75 (51/80) | 92.30 (12/13) | 58.20 (39/67) | 0.637 (0.515–0.759) | 0.034 |
HOXA9 + HOXD9 | 25.00 (10/40) | 97.50 (39/40) | 61.25 (49/80) | 90.90 (10/11) | 56.52 (39/69) | 0.612 (0.488–0.736) | 0.083 |
OPCML, HOXA9 and HOXD9 (≥ 2 marker) | 72.50 (29/40) | 95.00 (38/40) | 83.75 (67/80) | 93.54 (29/31) | 77.55 (38/49) | 0.837 (0.743–0.931) | < 0.0001 |
OPCML + HOXA9 + HOXD9 (3 markers) | 22.5 (9/40) | 100 (40/40) | 61.25 (49/80) | 100 (9/9) | 56.34 (40/71) | 0.613 (0.488–0.737) | 0.083 |