From: Epigenetic findings in periodontitis in UK twins: a cross-sectional study
Gene symbola | 450 K probes b | SNPs | Functional association with periodontitis or other diseases | References |
---|---|---|---|---|
NIN | 2 | rs12883458 | Genome-wide significant association with severe chronic periodontitis | Rhodin et al. [1] |
ABHD12B | 2 | rs12883458 | ||
WHAMM | 9 | rs2890313 | ||
KCNK1 | 0 | rs11800854 | Genome-wide significant association with red complex high colonization | |
DAB2IP | 0 | rs10760187 | Genome-wide significant association with Porphyromonas gingivalis high colonization | |
CLEC19A | 1 | rs1156327 | Genome-wide significant association with PCT1 (microbial community structure that has a high correlation and positive loading with all pathogens) | Offenbacher et al. [2] |
TRA | 0 | rs3811273 | ||
TM9SF2P | 1 | rs9557237 | ||
GGTA2P | 0 | rs17184007 | ||
IFI16 | 1 | rs1633266 | ||
RBMS3 | 0 | rs17718700 | ||
C1QTNF7 | 0 | rs4074082 | Genome-wide significant association with PCT3 (high positive loading of GCF-IL-1β and Aggregatibacter actinomycetemcomitans) | |
TSNARE | 1 | rs9772881 | ||
HPVC1 | 0 | rs10232172 | Genome-wide significant association with PCT4 (mixed-infection community with high positive loading of GCF-IL1, weak positive loadings of Pn, Pi, and Td, and low levels of Aa) | |
SLC15A4 | 1 | rs7135417 | Genome-wide significant association with PCT5 (chronic periodontitis) | |
PKP2 | 2 | rs6488099 | ||
SNRPN | 9 | rs904310 | ||
IL8 | 3 | Â | Regulation of innate and acquired immune response Increased in gingival crevicular fluid from patients with periodontitis | Zhan et al. [11] |
CD44 | 34 | Â | Smoking-induced periodontal tissue destruction | |
CXCL1 | 7 | Â | Stimulation of lipopolysaccharide in oral fibroblasts which leads to development of periodontal inflammation | |
IL6ST | 17 | Â | Signal transducer for the interleukin family; regulates osteoclasts and calcium homeostasis | |
CCR1 | 11 | Â | Trigger of bone resorption process | |
MMP7 | 7 | Â | Innate host defense in periodontal tissues | |
MMP13 | 10 | Â | Immunoreactivity in gingival crevicular fluid | |
MMP3 | 12 | Â | Physiological tissue remodeling of periodontal tissue | |
TLR9 | 0 | Â | Protective role against alveolar bone loss in the absence of Porphyromonas gingivalis | |
IL18 | 15 | Â | Inflammation and modulation of the activity of macrophages and neutrophils. Significantly higher in patients with chronic periodontitis compared to healthy controls | |
IFNB1 | 0 | Â | TNFa, via the autocrine action of IFNbeta, differentially regulates the expression of proinflammatory genes and DNA synthesis | |
GLT6D1 | 2 | rs1537415 | Genome-wide significant association with aggressive periodontitis | Schaefer et al. [12] |
IL1B | 8 | Â | The carriage rate of the R allele (frequency of N/R and R/R genotypes) among cases and controls | Laine et al. [13] |
IL1RN | 13 | Â | ||
IL6 | 14 | Â | ||
IL10 | 7 | Â | ||
VDR | 23 | Â | ||
CD14 | 29 | Â | ||
TLR4 | 4 | Â | ||
MMP1 | 11 | Â |