Table 1 MiRNAs involved in drug resistance regulation in various cancers

- Let-7b

Breast

−/TAM

ER-α36

[35]

Ovarian

+/Taxanes

IMP-1

[82]

- Let-7c

NSCLC

−/CDDP

ABCC2, BCL-XL

[57]

- Let-7e

Ovarian

−/CDDP

EZH2, CCND1

[194]

- 9

Ovarian

−/CDDP

BRCA1

[83]

- 10b

Colorectal

+/5-FU

BIM

[73]

- 15a/16

Breast

−/TAM

BCL-2 (BCL2)

[167]

- 15b

Lung

+/CDDP

PEBP4

[64]

- 17-5p

Lung

−/PTX

Beclin1

[195]

MCL

+/Topotecan

PHIPP2

[196]

Breast

−/Taxol

NCOA3

[197]

- 20a

Colorectal

+/5-FU,L-OHP, Teniposide

BNIP2

[74]

Breast

−/mutidrug

MAPK1

[198]

- 21

Ovarian

+/CDDP

PDCD4

[88]

Gastric

+/Trastuzumab

PTEN

[108]

Pancreas

+/GEM

FasL

[172]

Colorectal

+/5-FU

hMSH2

[72]

- 23a

Colorectal

+/5-FU

APAF-1

[75]

- 25

Gastric

+/CDDP

FOXO3a

[199]

- 26a/b

HCC

+/DOX

ULK1

[200]

- 26b

HCC

−/DOX

TAK1, TAB3

[201]

- 27a

Bladder

+/CDDP

SLC7A11

[202]

Lung

+/CDDP

RKIP

[65]

- 30a

Cervical,Breast, HCC

−/CDDP

Beclin1

[112]

- 30c

Breast

−/DOX

YWHAZ

[203]

- 30e

CML

−/Imatinib

ABL

[103]

- 31

NSCLC

+/CDDP

ABCB9

[58]

Ovarian

−/PTX

MET

[98]

- 34a

Breast

−/DOX

NOTCH1

[204]

Lung

−/CDDP

PEBP4

[67]

Breast

+/Docetaxel

BCL-2, CCND1

[37]

Prostate

−/PTX

SIRT1, BCL-2

[102]

Colorectal

−/5-FU

c-Kit

[77]

- 34c

Lung

+/PTX

BMF

[205]

- 92b

NSCLC

+/CDDP

PTEN

[68]

- 93

Ovarian

+/CDDP

PTEN

[89]

- 96

Colorectal

−/5-FU

XIAP

[76]

Breast, HCC

−/CDDP

RAD51, REV1

[43]

- 100

Pancreatic

−/CDDP

FGFR3

[114]

Lung

−/Docetaxel

PIK1

[206]

- 101

Ovarian

+/DOX

EZH2

[207]

- 103

Leukemia

−/CDDP

COP1

[208]

- 106a

Lung

+/CDDP

ABCA1

[63]

Ovarian

+/CDDP

PDCD4

[90]

Ovarian

−/CDDP

Mcl-1

[92]

- 122

Colon

−/5-FU

PKM2

[209]

- 125b

HCC

−/5-FU

Hexokinase II

[38]

Breast

+/5-FU

E2F3

[210]

APL

+/DOX

Bak1

[107]

- 126

NSCLC

−/DOX, VCR

VEGFA

[175]

- 130a

Ovarian

−/CDDP

XIAP

[93]

HCC

+/CDDP

RUNX3

[46]

Ovarian

+/CDDP

PTEN

[91]

- 130b

Ovarian

−/CDDP, PTX

CSF-1

[85]

Breast

+/DOX

PTEN

[211]

- 133a

HCC

−/DOX

ABCC1

[52]

- 134

Lung

+/Gefitinib

MAGI2

[212]

- 135a/b

Lung

−/CDDP

Mcl-1

[171]

- 136

Ovarian

−/PTX

Notch3

[213]

- 137

Breast

−/DOX

YB-1

[27]

Multiple myeloma

−/Bortezomib, Eprirubicin

AURKA

[214]

- 138

NSCLC

−/CDDP

ERCC1

[59]

NSCLC

−/Gefitinib

GPR124

[69]

- 141

Esophageal

+/CDDP

YAP1

[215]

HCC

+/5-FU

Keap1

[53]

- 143

Prostate

−/Docetaxel

KRAS

[101]

- 145

Ovarian

−/PTX

SP1, CDK6

[216]

- 148a

Prostate

−/PTX

MSK1

[100]

- 149

Breast

−/DOX

NDST1

[28]

- 153

Colorectal

+/L-OHP, CDDP

FOXO3a

[78]

- 155

Breast

+/DOX, VP-16, PTX

FOXO3a

[36]

- 181a

Breast

−/DOX

BCL-2

[32]

Cervical

+/CDDP

PRKCD

[217]

- 181b

Lung

−/VCR, CDDP

BCL-2

[109]

- 182

NSCLC

+/CDDP

PDCD4

[60]

HCC

+/CDDP

TP53INP1

[44]

- 183

Nasopharyngeal

−/CDDP

MTA1

[218]

- 190b

HCC

+/Insulin

IGF-1

[219]

- 193a-3p

HCC

+/5-FU

SRSF2

[54]

- 193b

HCC

−/Sorafenib

Mcl-1

[48]

- 195

Breast

−/DOX

Raf-1

[29]

Colon

−/DOX

BCL2L2

[165]

HCC

+/5-FU

BCL-w

[55]

Colon

−/5-FU

CHK1, WEE1

[220]

- 197

Ovarian

+/Taxol

NLK

[221]

- 199a-3p

HCC

−/DOX

mTOR, c-Met

[173]

- 199a-5p

HCC

−/CDDP

ATG7

[47]

- 199b-5p

Ovarian

−/CDDP

JAG1

[86]

- 200b

Prostate

−/Docetaxel

Bmi1

[222]

SCLC

−/CDDP,DOX,VP-16

ZEB2

[71]

Lung

−/Docetaxel

E2F3

[70]

Gastric, Lung

−/VCR, CDDP

BCL-2, XIAP

[169]

- 200c

Gastric

−/CDDP

RhoE

[110]

Breast

−/DOX

TrKB, Bmi1

[223]

Ovarian

−/PTX

TuBB3, TrKB

[96]

Breast

−/Trastuzumab

ZNF217, ZEB1

[224]

- 203

Glioblastoma

−/Imatinib,VP-16,TMZ

SNAI2

[225]

Colorectal

+/L-OHP

ATM

[226]

Colorectal

−/5-FU

TYMS

[79]

Breast

+/CDDP

SOCS3

[39]

- 205

NSCLC

+/CDDP

PTEN

[61]

- 214

Cervical

−/CDDP

Bcl2l2

[111]

Ovarian

+/CDDP

PTEN

[156]

- 216a/217

HCC

+/Sorafenib

PTEN, SMAD7

[49]

- 218

Breast

−/GEM

BIRC5

[227]

Gallbladder

−/DOX, Taxol

PRKCE

[228]

- 221

Breast

+/Trastuzumab

PTEN

[229]

- 223

HCC

−/DOX

ABCB1

[51]

Gastric

−/Trastuzumab

FBXW7

[230]

- 224

Lung

+/CDDP

P21(WAF1/CIP1)

[62]

- 298

Breast

−/DOX

MDR1

[184]

- 320

Colon

−/5-FU, L-OHP

FOXM1

[231]

- 320a

Breast

−/DOX

TRPC5, NFATC3

[33]

- 320c

Pancreatic

+/GEM

SMARCC1

[232]

- 328

Bresat

−/MX

ABCG2

[185]

- 337-3p

NSCLC

−/PTX

STAT3, RAP1A

[233]

- 338-3p

HCC

−/Sorafenib

HIF-1α

[234]

- 340

HCC

−/CDDP

Nrf2

[45]

- 370

Ovarian

−/CDDP

ENG

[84]

- 375

Breast

−/TAM

MTDH

[235]

- 449a

Ovarian

−/CDDP

NOTCH1

[87]

- 451

Colorectal

−/Irinotecan

COX-2

[236]

Breast

−/PTX

YWHAZ

[237]

- 452

Breast

−/DOX

IGF-1R

[30]

- 486

CML

+/Imatinib

FOXO1, PTEN

[105]

- 487a

Breast

−/MX

ABCG2

[186]

- 489

Ovarian

−/CDDP

Akt3

[31]

Breast

−/DOX

Smad3

[238]

- 491-3p

HCC

−/multidrug

ABCB1, SP3

[239]

- 497

Colorectal

−/5-FU

Smurf1

[240]

- 503

Lung

−/CDDP

BCL-2

[166]

Colorectal

+/L-OHP

PUMA

[241]

- 513a-3p

Lung

−/CDDP

GSTP1

[66]

- 519d

Breast

−/CDDP

MCL-1

[242]

- 591

Ovarian

−/PTX

ZEB1

[99]

- 587

Colorectal

+/5-FU

PPP2R1B

[243]

- 650

Lung

+/Docetaxel

ING4

[40]

- 663

Breast

+/Docetaxel, Cyclophosphamide

HSPG2

[244]

- 1915

Colorectal

−/L-OHP, DOX

BCL-2

[80]

- 3656

Pancreatic

−/GEM

RHOF

[245]