| FT3, pmol/L | FT4, pmol/L | TSH, mU/L |
---|
Variable | β | (95% CI) | β | (95% CI) | β | (95% CI) |
---|
mtDNA methylationa
|
 
MT-RNR1
| -1.50 | (-2.70 to -0.30)*
| -0.60 | (-1.04 to -0.16)*
| 0.38 | (-0.21 to 0.97) |
 
D-loop
| -0.46 | (-0.83 to -0.09)*
| -0.14 | (-0.28 to -0.002)*
| 0.11 | (-0.07 to 0.29) |
mtDNA contentb
| 20.35 | (0.47 to 44.17)*
| 11.04 | (4.00 to 18.54)**
| -5.34 | (-13.35 to 3.40) |
-
aβ represents an absolute change in placental mtDNA methylation percentage (%) for a 10th-90th percentile increment of cord blood thyroid hormone
-
bβ represents a relative change (%) in placental mtDNA content for a 10th-90th percentile increment of cord blood thyroid hormone
- All models are adjusted for maternal age, pre-pregnancy BMI, gestational age, newborn’s sex, smoking status, parity, maternal education, ethnicity, and cord plasma insulin level
-
*
p-value < 0.05, **
p-value < 0.005