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Fig. 2 | Clinical Epigenetics

Fig. 2

From: Identification of a methylation profile for DNMT1-associated autosomal dominant cerebellar ataxia, deafness, and narcolepsy

Fig. 2

a Methylation visualization of significantly altered gene GPR176 in ADCA-DN patients (black) and controls (grey) identified by methylation array. Figures were generated using genomic browser viewer (Partek) and show methylation levels 0 (not methylated) and 1 (100 % methylated) among controls and ADCA-DN patients. Location of CpG islands and genes are also represented. b Bisulfite mutagenesis and sequencing analysis of the GPR176 promoter region confirms effects seen by methylation array analysis. Twenty alleles from each sample were analysed, and individual alleles are represented as a string of CpGs. The total percent methylation for each sample is indicated. Unmethylated CpGs are represented as empty circles and methylated CpGs as filled circles

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