Fig. 5From: The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasisWestern blot analysis of apoptotic markers in Myc-induced cells in the presence of wild-type or mutated JMJD6. NMuMG cells were treated with 150Â nM 4-OHT to induce Myc or ethanol and placed in glucose- or glutamine-free media or treated with 100Â mM of etoposide. Expression of cleaved PARP and cleaved caspase 3 was determined by Western blot demonstrating reduced levels in the presence of wild-type, but not mutant, JMJD6Back to article page