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Fig. 1 | Clinical Epigenetics

Fig. 1

From: H3K4 tri-methylation breadth at transcription start sites impacts the transcriptome of systemic lupus erythematosus

Fig. 1

H3K4me3 at TSS. a The average H3K4me3 around TSS reduces by 50 % at ~400–500 bp upstream and ~600–700 bp downstream. This plot was based on the normalized average sequencing depth of six control samples. b Four distinctive patterns of TSS H3K4me3 were defined: narrow peak, upstream extended downstream extended, and broad symmetric. The same control samples were used for this plot. c Complementary pattern of other histone modifications to the downstream extended pattern of H3K4me3. Data of the other histone modifications in CD14+ monocyte were provided by the ENCODE project

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