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Table 2 Characteristics of the CpG sites significantly associated with HTGW

From: Genome- and epigenome-wide association study of hypertriglyceridemic waist in Mexican American families

Characteristic cg00574958 cg17058475 cg06500161
Chromosome 11 11 21
Coordinate 68607622 68607737 43656587
Gene symbol CPT1A CPT1A ABCG1
Gene context 5’UTR 5’UTR Body
Relation with CpG Island North shore North shore South shore
Presence of SNP within probe Yes No Yes
Minor allele frequency of probe SNP in cohort subset 0.0000 - 0.0279
Probe SNP ➔ Methylation association in cohort subset - - Not significant
Cross-reactivity None None None
Heritability 0.21 0.37 0.47
p heritability 2.7 × 10−5 3.5 × 10−10 2.2 × 10−15
Median β    
 HTGW 0.0831 0.0887 0.5831
 No HTGW 0.0929 0.0993 0.5667
Association with HTGWab    
   b −0.48 −0.44 0.36
   p 1.7 × 10−15 8.7 × 10−11 3.7 × 10−10
   q 7.9 × 10−10 4.0 × 10−5 1.7 × 10−4
Specificity of association with HTGWb    
   b −0.46 −0.40 0.32
   p 1.3 × 10−12 3.4 × 10−8 1.8 × 10−7
Association with HTGW and its components estimated through an interactive model
  High TG and WC    
    b −0.71 −0.53 0.73
    P 2.3 × 10−7 0.0002 5.3 × 10-8
  High WC only    
    b −0.22 −0.25 0.27
    P 5.7 × 10−5 0.0815 0.0002
  High TG only    
    b −0.20 0.05 0.47
    P 0.7969 0.2690 0.5328
Association with T2D that is mediated through HTGWc    
   b −0.16 −0.16 0.15
   P 0.0223 0.0180 0.0086
  1. b, p, and q indicate regression coefficient, nominal significance value, and significance level corrected for multiple testing (after correction for genomic inflation), respectively
  2. aAssociation between DNA methylation and HTGW after adjusting for age, age2, sex, age × sex interaction, and age2 × sex interaction, Illumina Sentrix® ID and Sentrix® position (to account for batch effects), use of anti-lipid, anti-hypertensive and anti-diabetic medications and cellular heterogeneity
  3. bAssociation between DNA methylation and HTGW after adjusting for age, age2, sex, age × sex interaction, and age2 × sex interaction, Illumina Sentrix® ID and Sentrix® position (to account for batch effects), use of anti-lipid, anti-hypertensive and anti-diabetic medications, cellular heterogeneity, presence of type 2 diabetes, obesity (body mass index ≥ 30 Kg/m2), systolic and diastolic blood pressure
  4. cMediation estimated using Sobel’s parameter [32]. All regression models were adjusted for age, age2, sex, age × sex interaction, and age2 × sex interaction, Illumina Sentrix® ID and Sentrix® position (to account for batch effects), use of anti-lipid, anti-hypertensive and anti-diabetic medications, and cellular heterogeneity
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Clinical Epigenetics

ISSN: 1868-7083

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