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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Analysis of DNA methylation landscape reveals the roles of DNA methylation in the regulation of drug metabolizing enzymes

Fig. 1

Heat maps of the DNA methylation profiles of the representative 6 CYP and 2 control genes by cluster analysis. The top of the map indicates samples from 20 normal adult livers (L1 to L81, NLA and NL2), 1 fetal liver (NLF), 1 adult small intestine (NSI), and 3 hepatoma cell lines. The right of the map indicates the target ID and gene name (CYP1A2, CYP1B1, CYP2C9, CYP2C19, CYP2D6, CYP3A4, ACTB, and BMP4) examined for individual CpG sites. The representative methylation profiles of individual genes were selected by excluding profiles showing the similar patterns each other. Therefore, the hierarchical similarity tree was not shown in the map. Higher DNA methylation levels are shown in red, while lower DNA methylation levels are shown in black

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