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Fig. 5 | Clinical Epigenetics

Fig. 5

From: Decreased efficacy of drugs targeting the vascular endothelial growth factor pathway by the epigenetic silencing of FLT1 in renal cancer cells

Fig. 5

FLT1 and KDR expression and the proliferation-inhibitory effects of sunitinib or axitinib after demethylation treatment. Promoter methylation and gene expression were evaluated after demethylation treatment in RCC lines. Changes in expression (RQ) and methylation (%) in FLT1 (a) and KDR (b) after demethylation using DAC, a demethylating agent. Proliferation of RCC lines following treatment with sunitinib or axitinib and/or DAC(c). The error bars show standard errors

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