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Fig. 2 | Clinical Epigenetics

Fig. 2

From: High cortisol in 5-year-old children causes loss of DNA methylation in SINE retrotransposons: a possible role for ZNF263 in stress-related diseases

Fig. 2

Differentially methylated regions were not affected by genetic variation or variation in blood cell type composition. a Manhattan plot of the results from the genetic association study covering 900 bp centered on each p < 0.0001 DMR (n = 852). Dots represent individual SNPs and red line the threshold for genome-wide significance. b Scatter plots illustrating the correlations between the relative minor allele frequencies of DMR-associated SNPs in Hi compared to Lo, and differential methylation of Hi compared to Lo of the same DMR. If a relationship between allele frequency and methylation level is present, higher relative frequency of alleles that cause gain of methylation sites in hypermethylated DMRs should result in a positive correlation, while the opposite relationship should be expected with alleles causing loss of methylation sites. In hypomethylated DMRs the reverse relationship is expected. c Overlap between the DMRs, or their nearest genes, and regions/genes from two independent studies reporting differential methylation between blood leukocytes; Reinius et al. 2012 [29] and Zilbauer et al. 2013 [30]

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