Triage of high-risk human papillomavirus-positive women by methylated POU4F3

Clinical Epigenetics

Table 4 Clinical performance of methylation biomarker in hrHPV-positive women of testing set stratified by histology

Total number of detectable		53	52	54
Detection modality		Gene name
Detection modality		POU4F3	HS3ST2	AJAP1
		Methylation positive/total number (%)
Result of pathology	Normal	0/5 (0 %)	0/5 (0 %)	0/5 (0 %)
	CIN1	2/13 (15.4 %)	0/14 (0 %)	5/14 (35.7 %)
	CIN3/CIS	15/24 (62.5 %)	8/22 (36.3 %)	17/24 (70.8 %)
	SCC/AC	11/11 (100 %)	10/11 (90.9 %)	11/11 (100 %)
	Total	28	18	33

CIN cervical intraepithelial neoplasia, CIN1 CIN grade 1, CIN3 CIN3 grade 3, CIS carcinoma in situ, SCC squamous cell carcinoma, AC adenocarcinoma

ISSN: 1868-7083