Table 1 RT-PCR data for a single dose of a panel of HKMT inhibitor compounds

1

Hit

HKMTI-1-005

4.05

3.65

3.12

0.63

2

Hit

HKMTI-1-022

4.28

29.4

11.56

0.21

3

Hit

HKMTI-1-11

6.95

33.25

6.25

0.22

4

G9ai

BIX01294

1.06

3.34

2.7

0.87

5

G9ai

UNC0638^a

1.1

5.5

3.4

0.4

6

EZH2i

GSK343

0.9

1.2

1.0

1.0

7

Negative

HKMTI-1-002

0.66

1.12

1.57

0.86

8

Negative

HKMTI-1-012

1.32

1.06

0.9

1.38

9

Negative

HKMTI-1-013

0.78

0.93

0.87

0.13