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Figure 4 | Clinical Epigenetics

Figure 4

From: Decreased expression of cell proliferation-related genes in clonally derived skin fibroblasts from children with Silver-Russell syndrome is independent of the degree of 11p15 ICR1 hypomethylation

Figure 4

Differential analysis results. (a) Venn diagram of differentially regulated genes in the SRShypo, SRSnormo, and Cnormo clones. (b) Differentially regulated genes in the SRShypo, SRSnormo, and Cnormo groups. Clustering heatmap based on multigroup comparison using the statistical parameters σ = 0.174, p = 0.05, and q = 0.529103 in Qlucore Omics Explorer 3.0. Ninety-two genes were significantly differentially expressed between the three groups. The analysis of the SRSnormo clone S1lo_7 is not shown. (c) Differentially expressed PRUNE2 in the SRShypo, SRSnormo, and Cnormo groups, as validated by qRT-PCR. qRT-PCR results were normalized to HepG2 cell gene expression. PRUNE2 is expressed at a significantly lower level in SRShypo compared to Cnormo (p = 0.017). (d) Differentially expressed IL6 in the SRShypo, SRSnormo, and Cnormo groups, as validated by qRT-PCR. qRT-PCR results were normalized to HepG2 cell gene expression. IL6 is expressed at a significantly higher level in SRShypo compared to Cnormo (p = 0.009).

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