Fig. 1From: Epigenetic regulation of mucin genes in human cancersSchematic model of MUC1 gene regulation through epigenetic modifications. Open chromatin is characterized by an unmethylated status of the MUC1 promoter and histones with acetylated H3-K9. This may allow assembly of transcription factors and transcription by RNA polymerase. DNA methylation and histone deacetylation result in condensation of chromatin into a compact state that is inaccessible to transcription factors. The MUC1 gene can also be posttranscriptionally regulated by miRNAs (miR-125b, miR-145, or miR-1226) that target the 3′-UTR of MUC1 mRNA and cause mRNA degradation or translational repressionBack to article page