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Cancer Epigenetics - Solid Tumors

Section information

Section Editors : Maria Berdasco and Carmen Jeronimo 

Associate Editors : Nita Ahuja, Tiziana Bonaldi (histones), Rene Cortese, James Flanagan (cervical/ovarian), Thomas Fleischer, Mario Fraga, Michéle Hoffmann (prostate), Bozena Kaminska (gliomas), Gwen Lomberk, Arpad Patai (colorectal/GI cancers), Qian Tao, Raul Urrutia, Stefan Wiemann (breast), Keishi Yamashita

The development of genome-wide techniques has rapidly improved the comprehensive knowledge of epigenetic alterations in cancer. Currently, a vast number of genes and their associated molecular pathways that show epigenetic differences between normal and tumoral cells have been identified, emphasizing the crucial role of epigenetic factors in cancer etiology and progression.  This section publishes original epigenetic research focused on the identification of epigenetic biomarkers associated with cancer diagnosis or tumor progression. Manuscripts on epigenetic biomarkers leading to a better definition of therapy response are also accepted (pharmacoepigenetics). Submissions on reports from human clinical trials providing insights on the clinical application of epigenetic biomarkers are welcomed.

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  1. We have previously developed a murine cellular system that models the transformation from melanocytes to metastatic melanoma cells. This model was established by cycles of anchorage impediment of melanocytes a...

    Authors: Hátylas Azevedo, Guilherme Cavalcante Pessoa, Francisca Nathália de Luna Vitorino, Jérémie Nsengimana, Julia Newton-Bishop, Eduardo Moraes Reis, Júlia Pinheiro Chagas da Cunha and Miriam Galvonas Jasiulionis
    Citation: Clinical Epigenetics 2020 12:127
    Content type: Research Published on:

  2. The high lethal rate of pancreatic cancer is partly due to a lack of efficient biomarkers for screening and early diagnosis. We attempted to develop effective and noninvasive methods using 5-methylcytosine (5m...

    Authors: Feng Cao, Ailin Wei, Xinlei Hu, Yijing He, Jun Zhang, Lin Xia, Kailing Tu, Jue Yuan, Ziheng Guo, Hongying Liu, Dan Xie and Ang Li
    Citation: Clinical Epigenetics 2020 12:112
    Content type: Research Published on:

  3. Canine mammary tumor (CMT) has long been considered as a good animal model for human breast cancer (HBC) due to their pathological and biological similarities. However, only a few aspects of the epigenome have...

    Authors: A-Reum Nam, Kang-Hoon Lee, Hyeon-Ji Hwang, Johannes J. Schabort, Jae-Hoon An, Sung-Ho Won and Je-Yoel Cho
    Citation: Clinical Epigenetics 2020 12:110
    Content type: Research Published on:

  4. Both colorectal (CRC, 15%) and endometrial cancers (EC, 30%) exhibit microsatellite instability (MSI) due to MLH1 hypermethylation and silencing. The MLH1 promoter polymorphism, rs1800734 is associated with MSI C...

    Authors: Holly Russell, Katarzyna Kedzierska, Daniel D. Buchanan, Rachael Thomas, Emma Tham, Miriam Mints, Anne Keränen, Graham G. Giles, Melissa C. Southey, Roger L. Milne, Ian Tomlinson, David Church, Amanda B. Spurdle, Tracy A. O’Mara and Annabelle Lewis
    Citation: Clinical Epigenetics 2020 12:102
    Content type: Short report Published on:

    The Correction to this article has been published in Clinical Epigenetics 2021 13:69

  5. A significant volume of research clearly shows that disease-related methylation changes can be used as biomarkers at all stages of clinical disease management, including risk assessment and predisposition scre...

    Authors: Olga Taryma-Leśniak, Katarzyna Ewa Sokolowska and Tomasz Kazimierz Wojdacz
    Citation: Clinical Epigenetics 2020 12:100
    Content type: Review Published on:

    The Correction to this article has been published in Clinical Epigenetics 2020 12:107

  6. Smoking status, alcohol consumption and HPV infection (acquired through sexual activity) are the predominant risk factors for oropharyngeal cancer and are thought to alter the prognosis of the disease. Here, w...

    Authors: Ryan Langdon, Rebecca Richmond, Hannah R. Elliott, Tom Dudding, Nabila Kazmi, Chris Penfold, Kate Ingarfield, Karen Ho, Andrew Bretherick, Chris Haley, Yanni Zeng, Rosie M. Walker, Michael Pawlita, Tim Waterboer, Tom Gaunt, George Davey Smith…
    Citation: Clinical Epigenetics 2020 12:95
    Content type: Research Published on:

  7. Small cell lung cancer (SCLC) is an aggressive neuroendocrine lung cancer. SCLC progression and treatment resistance involve epigenetic processes. However, links between SCLC DNA methylation and drug response ...

    Authors: Julia Krushkal, Thomas Silvers, William C. Reinhold, Dmitriy Sonkin, Suleyman Vural, John Connelly, Sudhir Varma, Paul S. Meltzer, Mark Kunkel, Annamaria Rapisarda, David Evans, Yves Pommier and Beverly A. Teicher
    Citation: Clinical Epigenetics 2020 12:93
    Content type: Research Published on:

  8. Despite rapid improvements in DNA methylation tools for cervical cancer screening, few robust, exploratory studies have been performed using the combination of two host genes, EPB41L3 and JAM3, newly developed as...

    Authors: Linghua Kong, Linhai Wang, Ziyun Wang, Xiaoping Xiao, Yan You, Huanwen Wu, Ming Wu, Pei Liu and Lei Li
    Citation: Clinical Epigenetics 2020 12:91
    Content type: Research Published on:

  9. Risk stratification for lung cancer (LC) screening is so far mostly based on smoking history. This study aimed to assess if and to what extent such risk stratification could be enhanced by additional considera...

    Authors: Haixin Yu, Janhavi R. Raut, Ben Schöttker, Bernd Holleczek, Yan Zhang and Hermann Brenner
    Citation: Clinical Epigenetics 2020 12:89
    Content type: Research Published on:

  10. Eukaryotic histone methyltransferases 2 (EHMT2 or G9A) has been regarded as a potential target for non-small cell lung cancer (NSCLC) therapy. This study investigated the regulatory roles of G9A in tumorigenes...

    Authors: Rajendra P. Pangeni, Lu Yang, Keqiang Zhang, Jinhui Wang, Wendong Li, Chao Guo, Xinwei Yun, Ting Sun, Jami Wang and Dan J. Raz
    Citation: Clinical Epigenetics 2020 12:88
    Content type: Research Published on:

  11. Cancer subtype switching, which involves unclear cancer cell origin, cell fate decision, and transdifferentiation of cells within a confined tumor microenvironment, remains a major problem in pancreatic cancer...

    Authors: Li-Yun Ding, Ya-Chin Hou, I-Ying Kuo, Ting-Yi Hsu, Tsung-Ching Tsai, Hsiu-Wei Chang, Wei-Yu Hsu, Chih-Chieh Tsao, Chung-Chen Tian, Po-Shun Wang, Hao-Chen Wang, Chung-Ta Lee, Yi-Ching Wang, Sheng-Hsiang Lin, Michael W. Hughes, Woei-Jer Chuang…
    Citation: Clinical Epigenetics 2020 12:87
    Content type: Research Published on:

  12. Breast cancer remains in urgent need of reliable diagnostic and prognostic markers. Zinc finger and BTB/POZ domain-containing family proteins (ZBTBs) are important transcription factors functioning as oncogene...

    Authors: Jin He, Mingjun Wu, Lei Xiong, Yijia Gong, Renjie Yu, Weiyan Peng, Lili Li, Li Li, Shaorong Tian, Yan Wang, Qian Tao and Tingxiu Xiang
    Citation: Clinical Epigenetics 2020 12:82
    Content type: Research Published on:

  13. The chromatin insulator CCCTC-binding factor (CTCF) displays tissue-specific DNA binding sites that regulate transcription and chromatin organization. Despite evidence linking CTCF to the protection of epigene...

    Authors: Nathan A. Damaschke, Joseph Gawdzik, Mele Avilla, Bing Yang, John Svaren, Avtar Roopra, Jian-Hua Luo, Yan P. Yu, Sunduz Keles and David F. Jarrard
    Citation: Clinical Epigenetics 2020 12:80
    Content type: Research Published on:

  14. The histone 3 lysine 4 (H3K4) monomethylase KMT2C is mutated across several cancer types; however, the effects of mutations on epigenome organization, gene expression, and cell growth are not clear. A frequent...

    Authors: Chatarina Larsson, Lina Cordeddu, Lee Siggens, Tatjana Pandzic, Snehangshu Kundu, Liqun He, Muhammad Akhtar Ali, Nuša Pristovšek, Karin Hartman, Karl Ekwall and Tobias Sjöblom
    Citation: Clinical Epigenetics 2020 12:74
    Content type: Research Published on:

  16. Epigenetic alterations are involved in most cancers, but its application in cancer diagnosis is still limited. More practical and intuitive methods to detect the aberrant expressions from clinical samples usin...

    Authors: Rulong Shen, Tong Cheng, Chuanliang Xu, Rex C. Yung, Jiandong Bao, Xing Li, Hongyu Yu, Shaohua Lu, Huixiong Xu, Hongxun Wu, Jian Zhou, Wenbo Bu, Xiaonan Wang, Han Si, Panying Shi, Pengcheng Zhao…
    Citation: Clinical Epigenetics 2020 12:71
    Content type: Methodology Published on:

  17. Gene silencing by aberrant DNA methylation of promoter regions remains the most dominant phenomenon occurring during tumorigenesis. Improving the early diagnosis, prognosis, and recurrence prediction of colore...

    Authors: Shih-Ching Chang, Phui-Ly Liew, Muhamad Ansar, Shih-Yun Lin, Sheng-Chao Wang, Chin-Sheng Hung, Jian-Yu Chen, Shikha Jain and Ruo-Kai Lin
    Citation: Clinical Epigenetics 2020 12:67
    Content type: Research Published on:

  18. Although HPV testing and cytology detection are successful for cervical screening in China, additional procedures are urgently required to avoid misdiagnosis and overtreatment. In this multicenter study, we co...

    Authors: Yuan-Yuan Gu, Guan-Nan Zhou, Qing Wang, Jing-Xin Ding and Ke-Qin Hua
    Citation: Clinical Epigenetics 2020 12:57
    Content type: Research Published on:

  19. Prostate cancer changes the phenotype of cells within the stromal microenvironment, including fibroblasts, which in turn promote tumour progression. Functional changes in prostate cancer-associated fibroblasts...

    Authors: Mitchell G. Lawrence, Ruth Pidsley, Birunthi Niranjan, Melissa Papargiris, Brooke A. Pereira, Michelle Richards, Linda Teng, Sam Norden, Andrew Ryan, Mark Frydenberg, Clare Stirzaker, Renea A. Taylor, Gail P. Risbridger and Susan J. Clark
    Citation: Clinical Epigenetics 2020 12:48
    Content type: Research Published on:

  20. Glial cell line-derived neurotrophic factor (GDNF) is highly expressed in glioblastoma (GBM) and blocking its expression can inhibit the initiation and development of GBM. GDNF is a dual promoter gene, and the pr...

    Authors: Baole Zhang, Xiaohe Gu, Xiao Han, Qing Gao, Jie Liu, Tingwen Guo and Dianshuai Gao
    Citation: Clinical Epigenetics 2020 12:47
    Content type: Research Published on:

  21. Heritable epigenetic alterations have been proposed as an explanation for familial clustering of melanoma. Here we performed genome-wide DNA methylation analysis on affected family members not carrying pathoge...

    Authors: Catarina Salgado, Nelleke Gruis, Bastiaan T. Heijmans, Jan Oosting and Remco van Doorn
    Citation: Clinical Epigenetics 2020 12:43
    Content type: Short report Published on:

  22. Nasopharyngeal carcinoma tends to present at an advanced stage because the primary anatomic site is located in a less visible area and its clinical symptoms are nonspecific. Prognosis of advanced nasopharyngea...

    Authors: Yu Jiang, Lei Liu, Qin Xiang, Xiaoqian He, Yan Wang, Dishu Zhou, Can Zou, Qian Chen, Mingyu Peng, Jin He, Xianyao Jiang, Tingxiu Xiang and Yucheng Yang
    Citation: Clinical Epigenetics 2020 12:41
    Content type: Research Published on:

  23. We had previously developed highly sensitive DNA methylation detection to diagnose lung cancer in patients with pulmonary nodules. To validate this approach and determine clinical utility in Chinese patients w...

    Authors: Chen Chen, Xiaojie Huang, Wei Yin, Muyun Peng, Fang Wu, Xia Wu, Jingqun Tang, Mingjiu Chen, Xiang Wang, Alicia Hulbert, Malcolm V. Brock, Wenliang Liu, James G. Herman and Fenglei Yu
    Citation: Clinical Epigenetics 2020 12:39
    Content type: Research Published on:

  24. Emerging evidence has shown that MUC1 and TFF2 play crucial roles in the H. pylori-infected pathogenesis of gastric cancer (GC). A recent study revealed that H. pylori infection induced obviously increased Tff2 m...

    Authors: Yuqiu Ge, Gaoxiang Ma, Hanting Liu, Yadi Lin, Gang Zhang, Mulong Du, Meilin Wang, Haiyan Chu, Haiyan Zhang and Zhengdong Zhang
    Citation: Clinical Epigenetics 2020 12:37
    Content type: Research Published on:

  25. While a considerable number of tumor-specific hypermethylated loci have been identified in renal cell cancer (RCC), DNA methylation of loci showing successive increases in normal, tumoral, and metastatic tissu...

    Authors: Jürgen Serth, Inga Peters, Natalia Dubrowinskaja, Christel Reese, Knut Albrecht, Michael Klintschar, Marcel Lafos, Alexander Grote, Albert Becker, Jörg Hennenlotter, Arnulf Stenzl, Hossein Tezval and Markus A. Kuczyk
    Citation: Clinical Epigenetics 2020 12:33
    Content type: Research Published on:

  26. The NuRD (Nucleosome Remodeling and Deacetylation) complex is a repressive complex in gene transcription by modulating chromatin accessibility of target genes to transcription factors and RNA polymerase II. Al...

    Authors: Simin Shao, Haowei Cao, Zhongkun Wang, Dongmei Zhou, Chaoshen Wu, Shu Wang, Dian Xia and Daoyong Zhang
    Citation: Clinical Epigenetics 2020 12:31
    Content type: Research Published on:

  27. Overcoming therapeutic resistance is one of the major hurdles in cancer care. One mechanism contributing to therapeutic resistance is a process in which epithelial cells switch to a mesenchymal state (epitheli...

    Authors: Eva Galle, Bernard Thienpont, Sarah Cappuyns, Tom Venken, Pieter Busschaert, Matthias Van Haele, Eric Van Cutsem, Tania Roskams, Jos van Pelt, Chris Verslype, Jeroen Dekervel and Diether Lambrechts
    Citation: Clinical Epigenetics 2020 12:27
    Content type: Research Published on:

  28. Radiation is an important therapeutic tool. However, radiotherapy has the potential to promote co-evolution of genetic and epigenetic changes that can drive tumour heterogeneity, formation of radioresistant ce...

    Authors: Anna Danielsson, Kristell Barreau, Teresia Kling, Magnus Tisell and Helena Carén
    Citation: Clinical Epigenetics 2020 12:26
    Content type: Research Published on:

  29. Upregulation of the histone methyltransferase enzyme EZH2 and its histone modification H3K27me3 has been linked to melanoma progression, metastasis, and resistance to immune checkpoint blockade (ICB). In clini...

    Authors: Friederike Hoffmann, Dennis Niebel, Pia Aymans, Sandra Ferring-Schmitt, Dimo Dietrich and Jennifer Landsberg
    Citation: Clinical Epigenetics 2020 12:24
    Content type: Research Published on:

  30. There are seven insulin-like growth factor binding proteins (IGFBPs) that bind insulin-like growth factors (IGFs). IGFBP like protein1 (IGFBPL1) is a new member of this family. The function and mechanism of IG...

    Authors: Yingge Liu, Meiying Zhang, Tao He, Weili Yang, Lidong Wang, Lirong Zhang and Mingzhou Guo
    Citation: Clinical Epigenetics 2020 12:22
    Content type: Research Published on:

  31. 5-Hydroxymethylcytosine (5hmC) is a novel epigenetic mark and may be involved in the mechanisms of tumorigenesis and malignant transformation. However, the role of 5hmC in ependymoma, the third most common bra...

    Authors: Tao Wu, Zhi-wei Zhang, Shiwei Li, Bo Wang, Zhijun Yang, Peng Li, Jing Zhang, Wei-min Tong, Chunde Li, Fu Zhao, Yamei Niu and Pinan Liu
    Citation: Clinical Epigenetics 2020 12:19
    Content type: Research Published on:

  32. Breast cancer (BRCA) is a heterogeneous disease, characterized by different histopathological and clinical features and responses to various therapeutic measures. Despite the research progress of DNA methylati...

    Authors: Xiao-Qiong Chen, Fan Zhang, Qi-Chen Su, Chi Zeng, Fu-Hui Xiao and Yu Peng
    Citation: Clinical Epigenetics 2020 12:16
    Content type: Research Published on:

  33. Increased numbers of myeloid-derived suppressor cells (MDSCs) are positively correlated with poor prognosis and reduced survivals of cancer patients. They play central roles in tumor immune evasion and tumor m...

    Authors: Varun Sasidharan Nair, Reem Saleh, Salman M. Toor, Rowaida Z. Taha, Ayman A. Ahmed, Mohamed A. Kurer, Khaled Murshed, Nehad M. Alajez, Mohamed Abu Nada and Eyad Elkord
    Citation: Clinical Epigenetics 2020 12:13
    Content type: Research Published on:

  34. Poor-responsiveness of tumors to radiotherapy is a major clinical problem. Owing to the dynamic nature of the epigenome, the identification and targeting of potential epigenetic modifiers may be helpful to cur...

    Authors: Asmita Sharda, Mudasir Rashid, Sanket Girish Shah, Ajit Kumar Sharma, Saurav Raj Singh, Poonam Gera, Murali Krishna Chilkapati and Sanjay Gupta
    Citation: Clinical Epigenetics 2020 12:4
    Content type: Research Published on:

  35. Epigenetic regulations play pivotal roles in tumorigenesis and cancer development. Disruptor of telomeric silencing-1-like (DOT1L), also known as KMT4, is the only identified histone methyltransferase that cat...

    Authors: Liqun Yang, Qian Lei, Lin Li, Jie Yang, Zhen Dong and Hongjuan Cui
    Citation: Clinical Epigenetics 2019 11:199
    Content type: Research Published on:

    The Correction to this article has been published in Clinical Epigenetics 2022 14:67

  36. Aberrations in DNA methylation are widespread in colon cancer (CC). Understanding origin and progression of DNA methylation aberrations is essential to develop effective preventive and therapeutic strategies. ...

    Authors: Faiza Noreen, Taya Küng, Luigi Tornillo, Hannah Parker, Miguel Silva, Stefan Weis, Giancarlo Marra, Roland Rad, Kaspar Truninger and Primo Schär
    Citation: Clinical Epigenetics 2019 11:196
    Content type: Research Published on:

  37. The epigenome plays a key role in cancer heterogeneity and drug resistance. Hence, a number of epigenetic inhibitors have been developed and tested in cancers. The major focus of most studies so far has been o...

    Authors: Chiara Facciotto, Julia Casado, Laura Turunen, Suvi-Katri Leivonen, Manuela Tumiati, Ville Rantanen, Liisa Kauppi, Rainer Lehtonen, Sirpa Leppä, Krister Wennerberg and Sampsa Hautaniemi
    Citation: Clinical Epigenetics 2019 11:192
    Content type: Methodology Published on:

  38. Until today, adult and pediatric clinical trials investigating single-agent or combinatorial HDAC inhibitors including vorinostat in solid tumors have largely failed to demonstrate efficacy. These results may ...

    Authors: Cornelis M. van Tilburg, Till Milde, Ruth Witt, Jonas Ecker, Thomas Hielscher, Angelika Seitz, Jens-Peter Schenk, Juliane L. Buhl, Dennis Riehl, Michael C. Frühwald, Arnulf Pekrun, Claudia Rossig, Regina Wieland, Christian Flotho, Uwe Kordes, Bernd Gruhn…
    Citation: Clinical Epigenetics 2019 11:188
    Content type: Research Published on:

  39. Emerging evidence indicates that dysregulation of microRNAs (miRNAs) contributes to cervical cancer (CC) tumorigenesis and development. Previous work showed that miR-484 which regulated the EMT process was obv...

    Authors: Yang Hu, Fuxia Wu, Yankun Liu, Qian Zhao and Hua Tang
    Citation: Clinical Epigenetics 2019 11:186
    Content type: Research Published on:

  40. Molecular signatures are being increasingly incorporated into cancer classification systems. DNA methylation-based central nervous system (CNS) tumor classification is being recognized as having the potential ...

    Authors: Shirin Karimi, Jeffrey A. Zuccato, Yasin Mamatjan, Sheila Mansouri, Suganth Suppiah, Farshad Nassiri, Phedias Diamandis, David G. Munoz, Kenneth D. Aldape and Gelareh Zadeh
    Citation: Clinical Epigenetics 2019 11:185
    Content type: Research Published on:

  41. Recent studies suggested that ZMYND10 is a potential tumor suppressor gene in multiple tumor types. However, the mechanism by which ZMYND10 inhibits breast cancer remains unclear. Here, we investigated the role a...

    Authors: Yan Wang, Liangying Dan, Qianqian Li, Lili Li, Lan Zhong, Bianfei Shao, Fang Yu, Sanxiu He, Shaorong Tian, Jin He, Qian Xiao, Thomas C. Putti, Xiaoqian He, Yixiao Feng, Yong Lin and Tingxiu Xiang
    Citation: Clinical Epigenetics 2019 11:184
    Content type: Research Published on:

    The Correction to this article has been published in Clinical Epigenetics 2022 14:36

  42. Cisplatin-based chemotherapy (CBCT) is part of standard treatment of several cancers. In testicular cancer (TC) survivors, an increased risk of developing metabolic syndrome (MetS) is observed. In this epigeno...

    Authors: Cecilie Bucher-Johannessen, Christian M. Page, Trine B. Haugen, Marcin W. Wojewodzic, Sophie D. Fosså, Tom Grotmol, Hege S. Haugnes and Trine B. Rounge
    Citation: Clinical Epigenetics 2019 11:179
    Content type: Research Published on:

  43. Gingivo-buccal oral squamous cell carcinoma (OSCC-GB) is the most common cancer among men in India and is associated with high mortality. Although OSCC-GB is known to be quite different from tongue cancer in i...

    Authors: Debodipta Das, Sahana Ghosh, Arindam Maitra, Nidhan K. Biswas, Chinmay K. Panda, Bidyut Roy, Rajiv Sarin and Partha P. Majumder
    Citation: Clinical Epigenetics 2019 11:178
    Content type: Research Published on:

  44. In order to gain insight into the contribution of DNA methylation to disease progression of chronic lymphocytic leukemia (CLL), using 450K Illumina arrays, we determined the DNA methylation profiles in paired ...

    Authors: Maria Tsagiopoulou, Nikos Papakonstantinou, Theodoros Moysiadis, Larry Mansouri, Viktor Ljungström, Martí Duran-Ferrer, Andigoni Malousi, Ana C. Queirós, Karla Plevova, Sujata Bhoi, Panagoula Kollia, David Oscier, Achilles Anagnostopoulos, Livio Trentin, Matthias Ritgen, Sarka Pospisilova…
    Citation: Clinical Epigenetics 2019 11:177
    Content type: Research Published on:

  45. Lung (LC), prostate (PCa) and colorectal (CRC) cancers are the most incident in males worldwide. Despite recent advances, optimal population-based cancer screening methods remain an unmet need. Due to its earl...

    Authors: Vera Constâncio, Sandra P. Nunes, Catarina Moreira-Barbosa, Rui Freitas, Jorge Oliveira, Inês Pousa, Júlio Oliveira, Marta Soares, Carlos Gonçalves Dias, Teresa Dias, Luís Antunes, Rui Henrique and Carmen Jerónimo
    Citation: Clinical Epigenetics 2019 11:175
    Content type: Research Published on:

  46. Constitutional MLH1 methylation (epimutation) is a rare cause of Lynch syndrome. Low-level methylation (≤ 10%) has occasionally been described. This study aimed to identify low-level constitutional MLH1 epimutati...

    Authors: Estela Dámaso, Júlia Canet-Hermida, Gardenia Vargas-Parra, Àngela Velasco, Fátima Marín, Esther Darder, Jesús del Valle, Anna Fernández, Àngel Izquierdo, Gemma Mateu, Glòria Oliveras, Carmen Escribano, Virgínia Piñol, Hugo-Ikuo Uchima, José Luis Soto, Megan Hitchins…
    Citation: Clinical Epigenetics 2019 11:171
    Content type: Short report Published on:

  47. An epigenetic field of cancer susceptibility exists for prostate cancer (PC) that gives rise to multifocal disease in the peripheral prostate. In previous work, genome-wide DNA methylation profiling identified...

    Authors: Bing Yang, Tyler Etheridge, Johnathon McCormick, Adam Schultz, Tariq A. Khemees, Nathan Damaschke, Glen Leverson, Kaitlin Woo, Geoffrey A. Sonn, Eric A. Klein, Mike Fumo, Wei Huang and David F. Jarrard
    Citation: Clinical Epigenetics 2019 11:168
    Content type: Research Published on:

  48. Glial cells in the central nervous system play a key role in neuroinflammation and subsequent central sensitization to pain. They are therefore involved in the development of persistent pain. One of the main s...

    Authors: Dario Kringel, Mari A. Kaunisto, Eija Kalso and Jörn Lötsch
    Citation: Clinical Epigenetics 2019 11:167
    Content type: Research Published on:

  49. Euchromatic histone-lysine-N-methyltransferases 1 and 2 (EHMT1/2, aka GLP/G9A) catalyze dimethylation of histone H3 lysine 9 (H3K9me2) and have roles in epigenetic silencing of gene expression. EHMT1/2 also have ...

    Authors: Zachary L. Watson, Tomomi M. Yamamoto, Alexandra McMellen, Hyunmin Kim, Connor J. Hughes, Lindsay J. Wheeler, Miriam D. Post, Kian Behbakht and Benjamin G. Bitler
    Citation: Clinical Epigenetics 2019 11:165
    Content type: Research Published on:

  50. Recently, it was shown that the epigenetic age of non-small cell lung cancer (NSCLC) tissues is different from the chronological age of patients. Here, we demonstrate that Regucalcin and Survivin, molecules wh...

    Authors: Dörte Nitschkowski, Sebastian Marwitz, Sousana A. Kotanidou, Martin Reck, Christian Kugler, Klaus F. Rabe, Ole Ammerpohl and Torsten Goldmann
    Citation: Clinical Epigenetics 2019 11:157
    Content type: Letter to the Editor Published on:

Clinical Epigenetics

ISSN: 1868-7083

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