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Fig. 6 | Clinical Epigenetics

Fig. 6

From: Genome-wide assessment of DNA methylation alterations induced by superovulation, sexual immaturity and in vitro follicle growth in mouse blastocysts

Fig. 6

DNA methylation in mouse blastocysts derived from in vitro follicle culture oocytes. a Beanplots indicating whole-genome DNA methylation levels in individual blastocysts. The beanplots depict the density distribution of % CpG methylation of evaluated 100-CpG tiles common to all datasets (n = 193,363); within each beanplot, boxplot shows median value and 25–75th percentiles and whiskers show the lowest and highest observation. b Methylation at gDMRs in mouse blastocysts derived from NO, SOA, SOp, IFCa and IFCp conditions. Each dot represents the combined methylation level of the gDMRs of an individual blastocyst. Boxplots show median value and 25–75th percentiles and whiskers show the lowest and highest observation. c Bar chart showing the proportion of reads that present full methylation, mixed methylation or full unmethylation at combined imprinted gDMRs in each individual blastocyst. d Strip chart and boxplot illustrating methylation at 16 gDMRs common to all blastocysts from the IFCa and IFCp conditions. Each dot represents the combined methylation level of an individual gDMR in the blastocysts of the respective group. Boxplots show median value and 25–75th percentiles and whiskers show the lowest and highest observation. gDMR, maternally methylated germline differentially methylated region; SOa, superovulation adult; IFCa, in vitro follicle adult; IFCp, in vitro follicle culture prepubertal

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