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Fig. 3 | Clinical Epigenetics

Fig. 3

From: Distinct modulation of IFNγ-induced transcription by BET bromodomain and catalytic P300/CBP inhibition in breast cancer

Fig. 3

BET inhibition disrupts BRD4 and RNA Pol II recruitment downstream of nucleosome acetylation. A Binding of IRF1 by ChIP-seq to IFNγ-induced loci following IFNγ ± JQ1. B Binding of P300 by ChIP-seq to IFNγ-induced loci following IFNγ ± JQ1. C Chromatin accessibility by ATAC-seq at IFNγ-induced loci following IFNγ ± JQ1. D Acetylation of H3K27 by ChIP-seq at IFNγ-induced loci following IFNγ ± JQ1. E Binding of BRD4 by ChIP-seq to IFNγ-induced loci following IFNγ ± JQ1. F RNA polymerase II occupancy by ChIP-seq across IFNγ stimulated genes following IFNγ ± JQ1. G Column-normalized heatmap of gene expression by RNA-seq for IFNγ stimulated genes in the presence of IFNγ ± JQ1. H Normalized counts (log2 counts per million) of Stat1 and Tap1 following IFNγ ± JQ1. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001, Mann–Whitney U test

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