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Fig. 1 | Clinical Epigenetics

Fig. 1

From: Distinct modulation of IFNγ-induced transcription by BET bromodomain and catalytic P300/CBP inhibition in breast cancer

Fig. 1

IFNγ evokes a concerted transcriptional response in cancer. A RNA-seq of AT3 cells stimulated with IFNγ. B Normalized counts (log2 counts per million) of IFNγ stimulated genes. C GSEA for AT3 cells stimulated with IFNγ. D Survival of breast cancer patients (from TCGA) stratified by expression of concordant IFNγ stimulated genes. E RNA polymerase II occupancy by ChIP-seq across IFNγ stimulated or non-IFNγ stimulated genes. F De novo motif analysis in promoters of IFNγ stimulated genes. G Distribution of IRF and ISRE motifs within promoters of IFNγ stimulated genes

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