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Table 3 Differentially methylated cytosines (DMCs; q < 0.05) that were increased post-surgery versus pre-surgery

From: Weight loss after Roux-En-Y gastric bypass surgery reveals skeletal muscle DNA methylation changes

Chr

Position

Gene

Pre-surgery methylation %

Post-surgery methylation %

P value

q value

Genic region

CpG region

chr2

27,498,318

DNAJC5G

51.83 ± 9.21

89.02 ± 2.98

1.01E−09

0.00067

utr5

InterCpgi

chr7

20,830,624

SP8

1.30 ± 0.84

13.90 ± 1.02

2.01E−09

0.00076

Intergenic

CpG_Island

chr1

228,504,058

OBSCN

42.29 ± 6.19

84.61 ± 2.99

3.28E−09

0.00109

Intron

CpG_Island

chr10

119,271,421

EMX2OS

42.57 ± 2.47

68.77 ± 3.23

6.08E−09

0.00161

Intergenic

InterCpgi

chr1

51,154,377

FAF1

92.12 ± 2.38

100 ± 0

1.16E−08

0.00220

Intron

InterCpgi

chr2

11,925,218

LPIN1

0 ± 0

9.68 ± 1.23

1.55E−07

0.01243

Intron

CpG_Island

chr1

240,347,650

FMN2

84.75 ± 4.18

99.35 ± 0.65

2.06E−07

0.01352

Intron

InterCpgi

chr4

57,068,530

KIAA1211

83.59 ± 2.29

98.25 ± 1.13

1.89E−07

0.01352

utr5

InterCpgi

chr18

13,431,993

C18orf1

84.39 ± 3.53

100 ± 0

3.16E−07

0.01820

Intron

InterCpgi

chr3

113,160,431

WDR52

13.71 ± 2.73

46.89 ± 6.19

3.49E−07

0.01886

Promoter

CpG_Island

chr13

96,414,410

DNAJC3

90.20 ± 2.64

100 ± 0

5.33E−07

0.02357

Intron

InterCpgi

chr1

197,108,554

ASPM

86.50 ± 4.35

100 ± 0

7.84E−07

0.03038

Intron

InterCpgi

chr17

5,462,805

NLRP1

80.80 ± 5.66

99.05 ± 0.95

7.90E−07

0.03038

Exon

InterCpgi

chr19

54,872,598

LAIR1

67.12 ± 6.27

93.87 ± 2.11

8.60E−07

0.03079

Exon

InterCpgi

chr11

36,512,043

TRAF6

40.53 ± 4.68

65.66 ± 3.25

8.80E−07

0.03079

Exon

InterCpgi

chr15

52,248,473

LEO1

18.60 ± 3.51

45.53 ± 4.24

9.21E−07

0.03131

Intron

InterCpgi

chr22

50,919,564

ADM2

2.23 ± 0.81

11.87 ± 1.89

1.17E−06

0.03742

Promoter

CpG_Island

chr7

135,258,846

NUP205

88.18 ± 3.66

100 ± 0

1.20E−06

0.03793

Intron

InterCpgi

chr1

93,172,465

EVI5

83.13 ± 3.46

100 ± 0

1.42E−06

0.04189

Intron

InterCpgi

chr12

133,125,172

FBRSL1

88.19 ± 3.33

100 ± 0

1.44E−06

0.04203

intron

North_shore

chr5

137,729,043

KDM3B

84.36 ± 3.76

96.62 ± 1.45

1.52E−06

0.04294

Exon

InterCpgi

chr3

9,989,586

PRRT3

45.47 ± 3.64

74.18 ± 3.58

1.49E−06

0.04294

Exon

CpG_Island

chrX

66,764,054

AR

15.74 ± 4.49

42.72 ± 2.58

1.67E−06

0.04508

utr5

CpG_Island

chr1

91,184,127

BARHL2

0 ± 0

2.97 ± 0.83

1.81E−06

0.04740

Promoter

CpG_Island

chr7

939,123

ADAP1

40.13 ± 9.99

74.26 ± 3.10

1.83E−06

0.04759

Exon

South_shelf

chr1

34,642,648

C1orf94

0 ± 0

7.35 ± 2.25

2.04E−06

0.04785

utr5

CpG_Island

chr7

71,562,951

CALN1

81.90 ± 4.23

98.70 ± 1.30

1.96E−06

0.04785

Intron

InterCpgi

chr14

105,353,824

KIAA0284

62.07 ± 7.36

90.15 ± 4.41

1.93E−06

0.04785

Exon

South_shelf

  1. Data are mean ± SEM. The P value is calculated from the MethylSig analysis. The q value is generated by Benjamini–Hochberg multiple testing correction