From: Weight loss after Roux-En-Y gastric bypass surgery reveals skeletal muscle DNA methylation changes
 | Lean | Pre-surgery obese | Post-surgery obese | P value versus Lean Pre | P value Pre versus Post | P value Lean versus Post |
---|---|---|---|---|---|---|
Sex | Four female | Seven female | Â | Â | Â | |
Age (years) | 38.5 ± 5.8 | 45.1 ± 3.6 | 45.3 ± 3.5 | NS | NS | NS |
Body mass index (kg/m2) | 23.2 ± 0.9 | 42.1 ± 2.2 | 35.3 ± 1.8 | < 0.001 | < 0.001 | < 0.01 |
Body fat (%) | 30.3 ± 1.0 | 46.4 ± 1.2 | 40.6 ± 1.3 | < 0.00001 | < 0.01 | < 0.001 |
Waist circumference (cm) | 83.5 ± 3.2 | 122.7 ± 6.3 | 109.4 ± 109.4 | < 0.01 | < 0.0001 | < 0.05 |
Systolic blood pressure (mmHg) | 102.3 ± 12.6 | 125.1 ± 3.9 | 119.1 ± 4.6 | NS | NS | NS |
Diastolic blood pressure (mmHg) | 59.8 ± 13.3 | 71.7 ± 2.0 | 75.1 ± 1.7 | NS | NS | NS |
Triglycerides (mg/dL) | 92.8 ± 7.8 | 121.9 ± 17.5 | 107.7 ± 11.2 | NS | NS | NS |
Cholesterol (mg/dL) | 202.3 ± 11.4 | 181.4 ± 13.2 | 151.5 ± 11.2 | NS | < 0.01 | < 0.05 |
High-density lipoprotein (mg/dL) | 63.0 ± 9.0 | 45.0 ± 2.7 | 45.0 ± 2.5 | < 0.05 | NS | < 0.05 |
Low-density lipoprotein (mg/dL) | 120.8 ± 7.6 | 112.1 ± 11.9 | 84.8 ± 10.5 | NS | < 0.01 | < 0.05 |
Hemoglobin A1c % | 5.3 ± 0.1 | 6.0 ± 0.2 | 5.7 ± 0.1 | < 0.05 | NS | < 0.05 |
Fasting plasma glucose (mg/dL) | 87.2 ± 3.1 | 104.2 ± 7.8 | 86.7 ± 3.1 | NS | < 0.05 | NS |
Fasting serum insulin (uIU/mL) | 7.9 ± 4.2 | 18.2 ± 2.7 | 7.5 ± 1.0 | < 0.01 | < 0.01 | NS |
M-value (mg/kg/min) | 6.7 ± 0.7 | 2.4 ± 0.3 | 2.9 ± 0.4 | < 0.001 | NS | < 0.001 |