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Fig. 3 | Clinical Epigenetics

Fig. 3

From: HDAC2 enhances esophageal squamous cell carcinoma development through down-regulating microRNA-503-5p and promoting CXCL10

Fig. 3

Silencing HDAC2 disturbs ESCC cell invasive and migrating properties and tumorigenesis in mice. a Transwell assay to detect ESCC cell migration and invasion abilities; b Xenografted tumor volume changes; c Xenografted tumors and tumor weight; d RT-qPCR to detect HDAC2 expression in xenografted tumor tissues; e RT-qPCR to detect miR-503-5p expression in xenografted tumor tissues; f HE staining to observe xenografted tumor tissues; g Relative Ki-67 expression in xenografted tumor tissues; h relative PCNA expression in xenografted tumor tissues; for all quantitative results, the data were expressed as mean ± standard deviation of three independent experiments. Discrepancies among multiple groups were assessed by one-way ANOVA; * P < 0.05 compared with the sh-NC group

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