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Fig. 7 | Clinical Epigenetics

Fig. 7

From: The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells

Fig. 7

Schematic mechanisms mediated by MPT0G211 in combination with doxorubicin or vincristine in acute leukemia cell lines. When combined with doxorubicin (DOXO), MPT0G211 induces Ku70 acetylation and impairs DNA repair machinery. Moreover, acetylated Ku70 releases BAX, thus promoting BAX-mediated apoptotic cell death. MPT0G211 also synergizes with vincristine (VCR) to disrupt microtubule dynamics

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Clinical Epigenetics

ISSN: 1868-7083

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