Table 3 Univariate and multivariate analyses of factors affecting DNAmAge and age acceleration residuals
From: Increased epigenetic age in normal breast tissue from luminal breast cancer patients
Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
Coef. | Std. err. | p > t | Coef. | Std. err. | p > t | |
DNAmAge | ||||||
Age | 0.712 | 0.039 | < 0.001 | 0.807 | 0.095 | < 0.001 |
Breast cancer vs controls | 6.551 | 2.78 | 0.021 | 4.489 | 1.663 | 0.009 |
BMI | 0.148 | 0.238 | 0.534 | 0.164 | 0.143 | 0.256 |
Current alcohol use | − 2.833 | 2.904 | 0.332 | – | – | – |
Smoking (py) | 0.407 | 0.16 | 0.013 | 0.177 | 0.075 | 0.022 |
Age at menarche | 0.322 | 0.959 | 0.738 | 0.948 | 0.49 | 0.057 |
Age at first live birth | 0.03 | 0.251 | 0.905 | – | – | – |
Count of live births | ||||||
1 | 2.292 | 5.494 | 0.678 | − 4.92 | 3.268 | 0.137 |
1+ | 14.395 | 2.887 | < 0.001 | − 1.536 | 2.138 | 0.475 |
Breast fed | 5.286 | 2.83 | 0.065 | – | – | – |
Post- vs pre-menopausal | 18.645 | 2.138 | < 0.001 | − 3.982 | 3.006 | 0.19 |
Hispanic | − 5.924 | 5.018 | 0.241 | − 3.921 | 3.223 | 0.228 |
Race | ||||||
White | − 0.059 | 5.815 | 0.992 | 0.709 | 3.088 | 0.819 |
African Americans | − 2.142 | 7.643 | 0.78 | 0.196 | 4.219 | 0.963 |
Age Acc. Residuals | ||||||
Age | 0.000 | 0.039 | 1 | 0.095 | 0.095 | 0.324 |
Breast cancer vs controls | 3.878 | 1.264 | 0.003 | 4.489 | 1.664 | 0.009 |
BMI | 0.117 | 0.11 | 0.288 | 0.164 | 0.143 | 0.256 |
Current alcohol use | − 2.484 | 1.349 | 0.068 | – | – | – |
Smoking (py) | 0.174 | 0.074 | 0.022 | 0.178 | 0.076 | 0.022 |
Age at menarche | 0.358 | 0.454 | 0.433 | 0.949 | 0.491 | 0.057 |
Age at first live birth | − 0.169 | 0.153 | 0.274 | – | – | – |
Count of live births | ||||||
1 | − 1.598 | 2.9 | 0.583 | − 4.92 | 3.268 | 0.137 |
1+ | 0.041 | 1.52 | 0.979 | − 1.536 | 2.138 | 0.475 |
Breast fed | − 2.28 | 1.315 | 0.086 | – | – | – |
Post vs pre-menopausal | − 1.351 | 1.335 | 0.314 | − 3.982 | 3.006 | 0.19 |
Hispanic | 0.636 | 2.342 | 0.786 | − 3.921 | 3.223 | 0.228 |
Race | ||||||
White | − 1.063 | 2.685 | 0.693 | 0.709 | 3.088 | 0.819 |
African Americans | 1.082 | 3.529 | 0.76 | 0.196 | 4.219 | 0.963 |