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Table 2 Association between cord blood DNA methylation and mid-childhood IgE (FDR threshold < 0.05). Results are expressed as the change in log(IgE) concentration per 1% increase in cord blood methylation value

From: Epigenome-wide association study of total serum immunoglobulin E in children: a life course approach

CpG

CHR

MAPINFO

Gene

Estimate

P value

FDR

cg06226630

4

48,493,420

ZAR1

− 0.40

1.15E−07

0.013

cg03307893

15

26,108,683

ATP10A

− 0.76

1.20E−07

0.013

cg13322072

7

98,784,083

KPNA7

− 0.11

1.23E−07

0.013

cg16797808

14

99,948,289

SETD3;CCNK

− 0.90

3.18E−07

0.023

cg09535168

19

19,431,582

MAU2

− 1.44

3.91E−07

0.023

cg04122974

22

39,916,495

ATF4

− 3.02

4.46E−07

0.023

cg01527777

11

71,956,145

PHOX2A

− 0.24

6.06E−07

0.027

cg24575275

7

1,094,737

C7orf50

− 0.29

9.23E−07

0.032

cg14920426

5

176,924,420

PDLIM7

− 1.00

1.01E−06

0.032

cg05399209

19

46,010,836

VASP

− 1.33

1.03E−06

0.032

cg09507928

5

140,027,484

IK;NDUFA2

− 2.03

1.46E−06

0.040

cg24114890

14

23,834,349

EFS

− 0.76

1.65E−06

0.040

cg05063806

1

36,772,417

C1orf113

− 1.26

1.79E−06

0.040

cg14167858

1

120,199,593

–

0.10

1.83E−06

0.040

cg02228675

17

40,259,724

DHX58

− 0.27

1.90E−06

0.040

cg14607755

9

139,962,279

C9orf140

− 0.49

2.25E−06

0.044

cg24630419

1

217,311,608

ESRRG

− 0.41

2.49E−06

0.046

cg27212903

15

92,708,880

SLCO3A1

0.97

2.91E−06

0.048

cg14605590

9

94,900,583

LOC100128076

− 0.16

2.93E−06

0.048

  1. Model adjusted for maternal [age at enrollment (continuous), smoking status (smoking during pregnancy/former/never), college graduate (yes/no), maternal atopy history (yes/no)], children [child’s sex (female/male), race/ethnicity (white/black/other), gestational age (continuous), age at blood drawn (continuous)], and the cell-type proxys using the first five ReFACTor components estimated from cord blood
  2. Corresponding model: log(IgE) = α0 + α1CpG_cbi + α2X2 + … + αpXp + ε